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移植后淋巴组织增生性疾病致食管溃疡和狭窄 1 例报告并文献复习

Post-transplant lymphoproliferative disorder as a cause of oesophageal ulceration and stricture: case report and literature review.

机构信息

Gastroenterology and Hepatology Residency Program, University of Toronto, Toronto, Ontario, Canada

Internal Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, Saudi Arabia.

出版信息

BMJ Open Gastroenterol. 2021 Feb;8(1). doi: 10.1136/bmjgast-2021-000602.

Abstract

Post-transplant lymphoproliferative disorder (PTLD) of the oesophagus is a rare complication of solid organ transplant that requires a high index of suspicion to diagnose. A literature review conducted on Ovid Medline database retrieved 24 articles, among which five previous cases of oesophageal PTLD were identified. Development of oesophageal strictures related to PTLD has not been reported in the literature. We report a case of oesophageal PTLD following lung transplant, presenting with extensive, circumferential ulceration in the oesophagus. PTLD was successfully treated with chemotherapy but subsequently, this patient developed a severe oesophageal stricture at the site of her PTLD. She presented with an episode of food bolus impaction requiring endoscopic retrieval. In the following years, our patient required multiple endoscopic dilatations of this PTLD-related oesophageal stricture.

摘要

食管移植后淋巴组织增生性疾病(PTLD)是实体器官移植的罕见并发症,需要高度怀疑才能诊断。在 Ovid Medline 数据库上进行的文献回顾检索到 24 篇文章,其中确定了 5 例以前的食管 PTLD 病例。文献中没有报道与 PTLD 相关的食管狭窄的发展。我们报告了一例肺移植后发生的食管 PTLD,表现为食管广泛的环状溃疡。PTLD 通过化疗成功治疗,但随后,该患者在 PTLD 部位发生严重的食管狭窄。她曾出现过一次食物团块嵌塞的发作,需要内镜取出。在随后的几年中,我们的患者需要多次内镜扩张来治疗这种与 PTLD 相关的食管狭窄。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1def/7925244/0b513ab5497f/bmjgast-2021-000602f01.jpg

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