• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

年轻人和老年人睡眠时的大脑功能网络。

Cerebral functional networks during sleep in young and older individuals.

机构信息

Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada.

Center for Advanced Research in Sleep Medicine (CARSM), Hôpital du Sacré-Cœur de Montréal, 5400 Gouin Boulevard West, Montreal, QC, H4J 1C5, Canada.

出版信息

Sci Rep. 2021 Mar 1;11(1):4905. doi: 10.1038/s41598-021-84417-0.

DOI:10.1038/s41598-021-84417-0
PMID:33649377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7921592/
Abstract

Even though sleep modification is a hallmark of the aging process, age-related changes in functional connectivity using functional Magnetic Resonance Imaging (fMRI) during sleep, remain unknown. Here, we combined electroencephalography and fMRI to examine functional connectivity differences between wakefulness and light sleep stages (N1 and N2 stages) in 16 young (23.1 ± 3.3y; 7 women), and 14 older individuals (59.6 ± 5.7y; 8 women). Results revealed extended, distributed (inter-between) and local (intra-within) decreases in network connectivity during sleep both in young and older individuals. However, compared to the young participants, older individuals showed lower decreases in connectivity or even increases in connectivity between thalamus/basal ganglia and several cerebral regions as well as between frontal regions of various networks. These findings reflect a reduced ability of the older brain to disconnect during sleep that may impede optimal disengagement for loss of responsiveness, enhanced lighter and fragmented sleep, and contribute to age effects on sleep-dependent brain plasticity.

摘要

尽管睡眠的改变是衰老过程的一个标志，但在睡眠过程中使用功能磁共振成像 (fMRI) 研究与年龄相关的功能连接变化仍然未知。在这里，我们结合脑电图和 fMRI 检查了 16 名年轻（23.1 ± 3.3 岁；7 名女性）和 14 名老年人（59.6 ± 5.7 岁；8 名女性）在清醒和轻度睡眠阶段（N1 和 N2 阶段）之间的功能连接差异。结果显示，在年轻人和老年人中，睡眠期间网络连接的扩展、分布式（间内）和局部（内）都出现了减少。然而，与年轻参与者相比，老年人在丘脑/基底神经节与几个大脑区域之间以及各个网络的额叶区域之间的连接减少较低，甚至出现连接增加。这些发现反映了老年人大脑在睡眠期间断开连接的能力降低，这可能会阻碍对反应能力丧失的最佳脱离，增强更轻和碎片化的睡眠，并导致年龄对睡眠相关脑可塑性的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/ce1ed39c52e1/41598_2021_84417_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/0a3aa0e1acff/41598_2021_84417_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/f3ded9da4fdd/41598_2021_84417_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/63d34e71eef0/41598_2021_84417_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/16c1651762a1/41598_2021_84417_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/ce1ed39c52e1/41598_2021_84417_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/0a3aa0e1acff/41598_2021_84417_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/f3ded9da4fdd/41598_2021_84417_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/63d34e71eef0/41598_2021_84417_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/16c1651762a1/41598_2021_84417_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1563/7921592/ce1ed39c52e1/41598_2021_84417_Fig5_HTML.jpg

相似文献

1
Cerebral functional networks during sleep in young and older individuals.年轻人和老年人睡眠时的大脑功能网络。
Sci Rep. 2021 Mar 1;11(1):4905. doi: 10.1038/s41598-021-84417-0.
2
Sleep spindles and hippocampal functional connectivity in human NREM sleep.人类非快速眼动睡眠中的睡眠梭形波和海马体功能连接。
J Neurosci. 2011 Jul 13;31(28):10331-9. doi: 10.1523/JNEUROSCI.5660-10.2011.
3
Large-scale brain functional modularity is reflected in slow electroencephalographic rhythms across the human non-rapid eye movement sleep cycle.大规模的大脑功能模块化反映在人类非快速眼动睡眠周期中的慢脑电节律中。
Neuroimage. 2013 Apr 15;70:327-39. doi: 10.1016/j.neuroimage.2012.12.073. Epub 2013 Jan 9.
4
State-dependent and region-specific alterations of cerebellar connectivity across stable human wakefulness and NREM sleep states.在稳定的人类清醒和非快速眼动睡眠状态下，小脑连接性的状态依赖性和区域特异性改变。
Neuroimage. 2023 Feb 1;266:119823. doi: 10.1016/j.neuroimage.2022.119823. Epub 2022 Dec 17.
5
Dynamic functional connectivity states characterize NREM sleep and wakefulness.动态功能连接状态表征了非快速眼动睡眠和觉醒状态。
Hum Brain Mapp. 2019 Dec 15;40(18):5256-5268. doi: 10.1002/hbm.24770. Epub 2019 Aug 24.
6
Cortical network functional connectivity in the descent to sleep.睡眠过程中皮质网络的功能连接性。
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4489-94. doi: 10.1073/pnas.0900924106. Epub 2009 Mar 2.
7
Functional connectivity during rested wakefulness predicts vulnerability to sleep deprivation.静息清醒状态下的功能连接性可预测睡眠剥夺的易感性。
Neuroimage. 2015 May 1;111:147-58. doi: 10.1016/j.neuroimage.2015.02.018. Epub 2015 Feb 17.
8
Development of a large-scale functional brain network during human non-rapid eye movement sleep.人类非快速眼动睡眠期间大规模功能大脑网络的发展。
J Neurosci. 2010 Aug 25;30(34):11379-87. doi: 10.1523/JNEUROSCI.2015-10.2010.
9
Development of the brain's default mode network from wakefulness to slow wave sleep.大脑默认模式网络从清醒到慢波睡眠的发展。
Cereb Cortex. 2011 Sep;21(9):2082-93. doi: 10.1093/cercor/bhq295. Epub 2011 Feb 17.
10
Hard to wake up? The cerebral correlates of sleep inertia assessed using combined behavioral, EEG and fMRI measures.难以醒来？使用综合行为、EEG 和 fMRI 测量评估的睡眠惯性的大脑相关性。
Neuroimage. 2019 Jan 1;184:266-278. doi: 10.1016/j.neuroimage.2018.09.033. Epub 2018 Sep 14.

引用本文的文献

1
Effects of gender and age on sleep EEG functional connectivity differences in subjects with mild difficulty falling asleep.性别和年龄对入睡轻度困难受试者睡眠脑电图功能连接差异的影响。
Front Psychiatry. 2024 Jul 9;15:1433316. doi: 10.3389/fpsyt.2024.1433316. eCollection 2024.
2
Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep.皮质同步和从觉醒到轻度非快速眼动睡眠过渡期间的信息流。
J Neurosci. 2023 Nov 29;43(48):8157-8171. doi: 10.1523/JNEUROSCI.0197-23.2023.
3
A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state.

本文引用的文献

1
A Standardized Protocol for Efficient and Reliable Quality Control of Brain Registration in Functional MRI Studies.功能磁共振成像研究中脑图谱配准高效可靠质量控制的标准化方案
Front Neuroinform. 2020 Feb 28;14:7. doi: 10.3389/fninf.2020.00007. eCollection 2020.
2
EEG connectivity across sleep cycles and age.脑电连接横跨睡眠周期和年龄。
Sleep. 2020 Mar 12;43(3). doi: 10.1093/sleep/zsz236.
3
Dynamic functional connectivity states characterize NREM sleep and wakefulness.动态功能连接状态表征了非快速眼动睡眠和觉醒状态。
丘脑活动的时间序列在行为唤醒状态的转变中展开。
Nat Commun. 2022 Sep 16;13(1):5442. doi: 10.1038/s41467-022-33010-8.
4
Unveiling whole-brain dynamics in normal aging through Hidden Markov Models.通过隐马尔可夫模型揭示正常衰老过程中的全脑动力学。
Hum Brain Mapp. 2022 Feb 15;43(3):1129-1144. doi: 10.1002/hbm.25714. Epub 2021 Nov 15.
Hum Brain Mapp. 2019 Dec 15;40(18):5256-5268. doi: 10.1002/hbm.24770. Epub 2019 Aug 24.
4
Sleep EEG functional connectivity varies with age and sex, but not general intelligence.睡眠脑电图功能连接随年龄和性别而变化，但与一般智力无关。
Neurobiol Aging. 2019 Jun;78:87-97. doi: 10.1016/j.neurobiolaging.2019.02.007. Epub 2019 Feb 21.
5
Intrinsic brain connectivity after partial sleep deprivation in young and older adults: results from the Stockholm Sleepy Brain study.年轻人和老年人部分睡眠剥夺后大脑的内在连通性：来自斯德哥尔摩睡眠大脑研究的结果。
Sci Rep. 2017 Aug 25;7(1):9422. doi: 10.1038/s41598-017-09744-7.
6
Increased interhemispheric resting-state functional connectivity in healthy participants with insomnia symptoms: A randomized clinical consort study.有失眠症状的健康参与者半球间静息态功能连接增加：一项随机临床联合研究。
Medicine (Baltimore). 2017 Jul;96(27):e7037. doi: 10.1097/MD.0000000000007037.
7
The large-scale functional connectivity correlates of consciousness and arousal during the healthy and pathological human sleep cycle.健康和病理人类睡眠周期中意识和觉醒的大规模功能连接相关性。
Neuroimage. 2017 Oct 15;160:55-72. doi: 10.1016/j.neuroimage.2017.06.026. Epub 2017 Jun 12.
8
Disrupted Topology of Frontostriatal Circuits Is Linked to the Severity of Insomnia.额前叶脑纹状体回路拓扑结构紊乱与失眠严重程度相关。
Front Neurosci. 2017 Apr 19;11:214. doi: 10.3389/fnins.2017.00214. eCollection 2017.
9
Sleep and Human Aging.睡眠与人类衰老
Neuron. 2017 Apr 5;94(1):19-36. doi: 10.1016/j.neuron.2017.02.004.
10
Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?睡眠：阿尔茨海默病病理学中的一种新型机制途径、生物标志物及治疗靶点？
Trends Neurosci. 2016 Aug;39(8):552-566. doi: 10.1016/j.tins.2016.05.002. Epub 2016 Jun 17.