• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SNHG7/miR-9-5p/DPP4 竞争 RNA 网络通过激活 PI3K/Akt 在甲状腺癌细胞生长和碘抵抗中的作用。

Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and I resistance of thyroid carcinoma cells through PI3K/Akt activation.

机构信息

Department of Thyroid Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

出版信息

Oncol Rep. 2021 Apr;45(4). doi: 10.3892/or.2021.7954. Epub 2021 Mar 2.

DOI:10.3892/or.2021.7954
PMID:33649840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7877006/
Abstract

Radioactive iodine (RAI, I) therapy is the main treatment for thyroid carcinoma (TC). Long noncoding RNA (lncRNA)/microRNA (miR) competing endogenous RNA (ceRNA) networks have aroused great interest for their roles in gene expression. The present study aimed to investigate the effect of lncRNA SNHG7 on the growth and I resistance of TC. Differentially expressed lncRNAs in TC and paracancerous tissues were analyzed. The binding of miR‑9‑5p with small nucleolar RNA host gene 7 (SNHG7) and dipeptidyl‑peptidase 4 (DPP4) was identified. Gain‑ and loss‑of‑function analyses of SNHG7 and miR‑9‑5p were performed to determine their effects on the growth and I resistance of TC cells. The activity of the PI3K/Akt pathway was evaluated. Consequently, upregulated SNHG7 was revealed in TC tissues and correlated with I resistance. Silencing of SNHG7 or overexpressing miR‑9‑5p inhibited the growth and I resistance of TC cells. SNHG7 acted as a ceRNA of miR‑9‑5p to enhance DPP4 expression. Overexpressed SNHG7 increased DPP4 expression and activated the PI3K/Akt signaling pathway by sponging miR‑9‑5p. The results were reproduced . In summary, the present study provided evidence that the SNHG7/miR‑9‑5p/DPP4 ceRNA network could promote the growth and I resistance of TC cells via PI3K/Akt activation. The present study may offer novel options for TC treatment.

摘要

放射性碘（RAI，I）治疗是甲状腺癌（TC）的主要治疗方法。长链非编码 RNA（lncRNA）/microRNA（miR）竞争内源性 RNA（ceRNA）网络因其在基因表达中的作用而引起了极大的兴趣。本研究旨在探讨 lncRNA SNHG7 对 TC 生长和碘抵抗的影响。分析 TC 和癌旁组织中差异表达的 lncRNA。鉴定了 miR-9-5p 与小核仁 RNA 宿主基因 7（SNHG7）和二肽基肽酶 4（DPP4）的结合。进行了 SNHG7 和 miR-9-5p 的增益和缺失功能分析，以确定它们对 TC 细胞生长和碘抵抗的影响。评估了 PI3K/Akt 通路的活性。结果表明，TC 组织中 SNHG7 上调，与碘抵抗相关。沉默 SNHG7 或过表达 miR-9-5p 抑制 TC 细胞的生长和碘抵抗。SNHG7 作为 miR-9-5p 的 ceRNA 增强 DPP4 的表达。过表达的 SNHG7 通过海绵吸附 miR-9-5p 增加 DPP4 的表达并激活 PI3K/Akt 信号通路。结果得以重现。总之，本研究提供了证据表明，SNHG7/miR-9-5p/DPP4 ceRNA 网络可通过激活 PI3K/Akt 促进 TC 细胞的生长和碘抵抗。本研究可能为 TC 的治疗提供新的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/d2bfdf1120af/or-45-04-7954-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/dd5b9bd47589/or-45-04-7954-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/193bff8ed157/or-45-04-7954-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/d5e3fe0e622d/or-45-04-7954-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/c40f410bf5a0/or-45-04-7954-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/721e1bf67718/or-45-04-7954-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/58028913c642/or-45-04-7954-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/aa08e4fc0827/or-45-04-7954-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/d2bfdf1120af/or-45-04-7954-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/dd5b9bd47589/or-45-04-7954-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/193bff8ed157/or-45-04-7954-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/d5e3fe0e622d/or-45-04-7954-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/c40f410bf5a0/or-45-04-7954-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/721e1bf67718/or-45-04-7954-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/58028913c642/or-45-04-7954-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/aa08e4fc0827/or-45-04-7954-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b48/7877006/d2bfdf1120af/or-45-04-7954-g07.jpg

相似文献

1
Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and I resistance of thyroid carcinoma cells through PI3K/Akt activation.SNHG7/miR-9-5p/DPP4 竞争 RNA 网络通过激活 PI3K/Akt 在甲状腺癌细胞生长和碘抵抗中的作用。
Oncol Rep. 2021 Apr;45(4). doi: 10.3892/or.2021.7954. Epub 2021 Mar 2.
2
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.长链非编码 RNA-SNHG7 作为 miR-34a 的靶标增加 GALNT7 水平并调节结直肠癌进展中的 PI3K/Akt/mTOR 通路。
J Hematol Oncol. 2018 Jul 3;11(1):89. doi: 10.1186/s13045-018-0632-2.
3
Downregulation of NEAT1 reverses the radioactive iodine resistance of papillary thyroid carcinoma cell via miR-101-3p/FN1/PI3K-AKT signaling pathway.下调 NEAT1 通过 miR-101-3p/FN1/PI3K-AKT 信号通路逆转甲状腺乳头状癌细胞的放射性碘抵抗。
Cell Cycle. 2019 Jan;18(2):167-203. doi: 10.1080/15384101.2018.1560203. Epub 2018 Dec 30.
4
Roles of a TMPO-AS1/microRNA-200c/TMEFF2 ceRNA network in the malignant behaviors and 5-FU resistance of ovarian cancer cells.TMPO-AS1/miRNA-200c/TMEFF2 环状 RNA 网络在卵巢癌细胞恶性行为和 5-FU 耐药中的作用。
Exp Mol Pathol. 2020 Aug;115:104481. doi: 10.1016/j.yexmp.2020.104481. Epub 2020 Jun 1.
5
LncRNA NEAT1 enhances the resistance of anaplastic thyroid carcinoma cells to cisplatin by sponging miR‑9‑5p and regulating SPAG9 expression.长链非编码 RNA NEAT1 通过海绵吸附 miR-9-5p 并调节 SPAG9 表达来增强甲状腺未分化癌细胞对顺铂的耐药性。
Int J Oncol. 2019 Nov;55(5):988-1002. doi: 10.3892/ijo.2019.4868. Epub 2019 Sep 4.
6
LncRNA GAS5 sponges miR-362-5p to promote sensitivity of thyroid cancer cells to I by upregulating SMG1.长链非编码 RNA GAS5 通过上调 SMG1 来吸附 miR-362-5p 从而促进甲状腺癌细胞对 I 的敏感性。
IUBMB Life. 2020 Nov;72(11):2420-2431. doi: 10.1002/iub.2365. Epub 2020 Aug 27.
7
LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling.LncRNA XIST/miR-34a 轴通过 MET-PI3K-AKT 信号通路调节甲状腺癌细胞增殖和肿瘤生长。
J Exp Clin Cancer Res. 2018 Nov 21;37(1):279. doi: 10.1186/s13046-018-0950-9.
8
The function of SNHG7/miR-449a/ACSL1 axis in thyroid cancer.SNHG7/miR-449a/ACSL1 轴在甲状腺癌中的作用。
J Cell Biochem. 2020 Oct;121(10):4034-4042. doi: 10.1002/jcb.29569. Epub 2020 Jan 21.
9
SNHG7 mediates cisplatin-resistance in non-small cell lung cancer by activating PI3K/AKT pathway.SNHG7 通过激活 PI3K/AKT 通路介导非小细胞肺癌对顺铂的耐药性。
Eur Rev Med Pharmacol Sci. 2019 Aug;23(16):6935-6943. doi: 10.26355/eurrev_201908_18733.
10
STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p/STAT3 axis and PI3K/AKT signalling pathway.STAT3 诱导的长链非编码 RNA ABHD11-AS1 的上调通过调节 miR-1301-3p/STAT3 轴和 PI3K/AKT 信号通路促进甲状腺乳头状癌的肿瘤进展。
Cell Prolif. 2019 Mar;52(2):e12569. doi: 10.1111/cpr.12569. Epub 2019 Jan 18.

引用本文的文献

1
High risk factors, molecular features and clinical management for radioactive iodine-refractory differentiated thyroid carcinoma.放射性碘难治性分化型甲状腺癌的高危因素、分子特征及临床管理
Front Oncol. 2025 Aug 25;15:1644562. doi: 10.3389/fonc.2025.1644562. eCollection 2025.
2
Unlocking the life code: a review of SnoRNA functional diversity and disease relevance.解锁生命密码：小核仁RNA功能多样性及与疾病相关性综述
Cell Commun Signal. 2025 Jun 4;23(1):266. doi: 10.1186/s12964-025-02274-0.
3
Exploring the enigma: history, present, and future of long non-coding RNAs in cancer.

本文引用的文献

1
MicroRNA-26a-5p inhibits proliferation, invasion and metastasis by repressing the expression of Wnt5a in papillary thyroid carcinoma.微小RNA-26a-5p通过抑制Wnt5a在甲状腺乳头状癌中的表达来抑制其增殖、侵袭和转移。
Onco Targets Ther. 2019 Aug 16;12:6605-6616. doi: 10.2147/OTT.S205994. eCollection 2019.
2
SNHG7 mediates cisplatin-resistance in non-small cell lung cancer by activating PI3K/AKT pathway.SNHG7 通过激活 PI3K/AKT 通路介导非小细胞肺癌对顺铂的耐药性。
Eur Rev Med Pharmacol Sci. 2019 Aug;23(16):6935-6943. doi: 10.26355/eurrev_201908_18733.
3
lncRNA SNHG7 sponges miR-425 to promote proliferation, migration, and invasion of hepatic carcinoma cells via Wnt/β-catenin/EMT signalling pathway.
探索谜团：癌症中长链非编码RNA的历史、现状与未来
Discov Oncol. 2024 Jun 7;15(1):214. doi: 10.1007/s12672-024-01077-y.
4
The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming.非编码RNA在癌症代谢重编程中的作用及分子机制。
Cancer Cell Int. 2024 Jan 18;24(1):37. doi: 10.1186/s12935-023-03186-0.
5
Interaction among long non-coding RNA, micro-RNA and mRNA in glioma.胶质瘤中长链非编码RNA、微小RNA与信使RNA之间的相互作用
Ibrain. 2021 Jun 28;7(2):141-145. doi: 10.1002/j.2769-2795.2021.tb00076.x. eCollection 2021 Jun.
6
DPP4 Is a Potential Prognostic Marker of Thyroid Carcinoma and a Target for Immunotherapy.二肽基肽酶4是甲状腺癌的潜在预后标志物及免疫治疗靶点。
Int J Endocrinol. 2022 Nov 24;2022:5181386. doi: 10.1155/2022/5181386. eCollection 2022.
7
Radio-lncRNAs: Biological Function and Potential Use as Biomarkers for Personalized Oncology.放射性长链非编码RNA：生物学功能及作为个性化肿瘤学生物标志物的潜在用途
J Pers Med. 2022 Sep 29;12(10):1605. doi: 10.3390/jpm12101605.
8
The Mechanism of Long Non-coding RNA in Cancer Radioresistance/Radiosensitivity: A Systematic Review.长链非编码RNA在癌症放射抗性/放射敏感性中的机制：一项系统综述
Front Pharmacol. 2022 May 5;13:879704. doi: 10.3389/fphar.2022.879704. eCollection 2022.
9
Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials.小核仁RNA宿主基因7（SNHG7）长链非编码RNA在人类癌症中的致癌作用及潜力
Front Cell Dev Biol. 2022 Jan 17;9:809345. doi: 10.3389/fcell.2021.809345. eCollection 2021.
10
Protein profiling reveals potential isomiR-associated cross-talks among RNAs in cholangiocarcinoma.蛋白质谱分析揭示了胆管癌中RNA之间潜在的与异源微小RNA相关的相互作用。
Comput Struct Biotechnol J. 2021 Oct 14;19:5722-5734. doi: 10.1016/j.csbj.2021.10.014. eCollection 2021.
lncRNA SNHG7 通过海绵吸附 miR-425 促进肝癌细胞增殖、迁移和侵袭，并激活 Wnt/β-catenin/EMT 信号通路。
Cell Biochem Funct. 2019 Oct;37(7):525-533. doi: 10.1002/cbf.3429. Epub 2019 Sep 2.
4
Long non-coding RNA (lncRNA) small nucleolar RNA host gene 7 (SNHG7) promotes breast cancer progression by sponging miRNA-381.长链非编码 RNA（lncRNA）小核仁 RNA 宿主基因 7（SNHG7）通过海绵吸附 miRNA-381 促进乳腺癌的进展。
Eur Rev Med Pharmacol Sci. 2019 Aug;23(15):6588-6595. doi: 10.26355/eurrev_201908_18545.
5
Downregulation of lncRNA SNHG7 inhibits proliferation and invasion of nasopharyngeal carcinoma cells through repressing ROCK1.长链非编码 RNA SNHG7 的下调通过抑制 ROCK1 抑制鼻咽癌细胞的增殖和侵袭。
Eur Rev Med Pharmacol Sci. 2019 Jul;23(14):6186-6193. doi: 10.26355/eurrev_201907_18432.
6
Parthenolide Inhibits the Proliferation of MDA-T32 Papillary Thyroid Carcinoma Cells in Vitro and in Mouse Tumor Xenografts and Activates Autophagy and Apoptosis by Downregulation of the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Signaling Pathway.小白菊内酯通过下调雷帕霉素靶蛋白（mTOR）/PI3K/AKT 信号通路抑制体外 MDA-T32 甲状腺乳头状癌细胞增殖和小鼠肿瘤异种移植瘤生长并诱导自噬和凋亡。
Med Sci Monit. 2019 Jul 8;25:5054-5061. doi: 10.12659/MSM.915387.
7
Long noncoding RNA SNHG7 represses the expression of RBM5 to strengthen metastasis of hepatocellular carcinoma.长链非编码 RNA SNHG7 抑制 RBM5 的表达，从而增强肝癌的转移。
Eur Rev Med Pharmacol Sci. 2019 Jul;23(13):5699-5704. doi: 10.26355/eurrev_201907_18307.
8
miR-29a inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting DPP4.微小RNA-29a通过靶向二肽基肽酶4抑制甲状腺乳头状癌的增殖、侵袭和迁移。
Onco Targets Ther. 2019 May 28;12:4225-4233. doi: 10.2147/OTT.S201532. eCollection 2019.
9
Knockdown of long noncoding RNA SNHG7 inhibits the proliferation and promotes apoptosis of thyroid cancer cells by downregulating BDNF.敲低长链非编码 RNA SNHG7 通过下调 BDNF 抑制甲状腺癌细胞的增殖并促进其凋亡。
Eur Rev Med Pharmacol Sci. 2019 Jun;23(11):4815-4821. doi: 10.26355/eurrev_201906_18067.
10
MicroRNA-9 enhances chemotherapy sensitivity of glioma to TMZ by suppressing TOPO II via the NF-κB signaling pathway.微小RNA-9通过核因子κB信号通路抑制拓扑异构酶II，增强胶质瘤对替莫唑胺的化疗敏感性。
Oncol Lett. 2019 Jun;17(6):4819-4826. doi: 10.3892/ol.2019.10158. Epub 2019 Mar 18.