类风湿关节炎患者停用非甾体抗炎治疗后的血清胞苷脱氨酶水平
Serum cytidine deaminase levels after withdrawal of non-steroidal anti-inflammatory treatment in rheumatoid arthritis.
作者信息
Thompson P W, Kirwan J R, Jones D D, Currey H L
机构信息
Bone and Joint Research Unit, London Hospital Medical College.
出版信息
Ann Rheum Dis. 1988 Apr;47(4):308-12. doi: 10.1136/ard.47.4.308.
Increases in joint inflammation in nine patients with rheumatoid arthritis were provoked by withdrawal of their non-steroidal anti-inflammatory drugs. Pain score, duration of morning stiffness, Ritchie articular index score, and the number of analgesic tablets consumed reached peaks after five, three, five, and five days respectively compared with values during six days of normal treatment. Changes in serum cytidine deaminase (believed to reflect polymorph turnover in inflamed joints) showed a different pattern, with a sharp peak after two days and a subsequent trough. Possible mechanisms for these differences are discussed.
9例类风湿性关节炎患者停用非甾体抗炎药后出现关节炎症加重。与正常治疗6天期间的值相比，疼痛评分、晨僵持续时间、里奇关节指数评分以及服用的止痛片数量分别在停药后5天、3天、5天和5天达到峰值。血清胞苷脱氨酶的变化（被认为反映了炎症关节中多形核细胞的更新）呈现出不同的模式，在停药后2天出现一个 sharp peak，随后出现低谷。文中讨论了这些差异的可能机制。 （注：原文中“sharp peak”直译为“尖锐峰值”，结合语境这里意译为“急剧峰值”更合适，但按要求不添加解释，所以保留原文英文表述）
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