类风湿关节炎患者滑液中的胞苷脱氨酶活性：与乳铁蛋白、酸中毒及软骨蛋白聚糖释放的关系
Cytidine deaminase activity in synovial fluid of patients with rheumatoid arthritis: relation to lactoferrin, acidosis, and cartilage proteoglycan release.
作者信息
Månsson B, Geborek P, Saxne T, Björnsson S
机构信息
Department of Rheumatology, University Hospital of Lund, Sweden.
出版信息
Ann Rheum Dis. 1990 Aug;49(8):594-7. doi: 10.1136/ard.49.8.594.
Abstract
It is claimed that cytidine deaminase activity reflects local granulocyte turnover or activity in the synovial fluid of patients with rheumatoid arthritis, but cytidine deaminase is not a granulocyte specific enzyme. Lactoferrin is a granulocyte specific protein that is released from the secondary granulae during activation. We measured cytidine deaminase activity and lactoferrin concentrations in 33 rheumatic synovial fluid samples. Cytidine deaminase activity and lactoferrin concentrations correlated closely, indicating that both analyses reflect similar events in the joint-that is, result in their release from granulocytes. Cytidine deaminase activity and granulocyte concentrations correlated less closely, suggesting that there are additional factors besides the cell number which contribute to this release. Joint acidosis may be one such factor, as pH and cytidine deaminase activity correlated inversely. There was no association with synovial fluid proteoglycan concentrations, a marker of cartilage degradation.
摘要
据称，胞苷脱氨酶活性反映类风湿性关节炎患者滑液中局部粒细胞更新或活性，但胞苷脱氨酶并非粒细胞特异性酶。乳铁蛋白是一种粒细胞特异性蛋白，在激活过程中从次级颗粒中释放出来。我们测量了33份风湿性滑液样本中的胞苷脱氨酶活性和乳铁蛋白浓度。胞苷脱氨酶活性与乳铁蛋白浓度密切相关，表明这两种分析反映了关节中相似的事件，即它们从粒细胞中释放出来。胞苷脱氨酶活性与粒细胞浓度的相关性较弱，这表明除细胞数量外，还有其他因素导致这种释放。关节酸中毒可能是其中一个因素，因为pH值与胞苷脱氨酶活性呈负相关。与滑液蛋白聚糖浓度（软骨降解的标志物）无关。
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