de Almeida M A, Izquierdo I
Departamento de Bioquimica, Instituto de Biociencias, U.F.R.G.S. (Centro), Porto Alegre, Brasil.
Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:202-7.
The immediate posttraining intracerebroventricular injection of histamine (1 or 10 ng/rat) facilitated memory both of a stepdown inhibitory avoidance task, and of the habituation of rearing responses to an open field. As previously shown for the avoidance task, the combination of cimetidine (1,000 ng/rat) plus prometazine (1,000 ng/rat), but not each drug on its own, blocked the effect of histamine in the habituation task. The effect of histamine was not shared by the intracerebroventricular administration of the mast cell histamine releaser, 48/80 (0.1 to 100 micrograms/rat). The present findings indicate that the memory facilitatory action of histamine might be general across tasks, and that 48/80-releasable, presumably mast cell, endogenous histamine is probably not involved in memory regulation.
训练后立即脑室内注射组胺（1或10纳克/大鼠）可促进对一步抑制性回避任务的记忆以及对旷场中竖毛反应习惯化的记忆。如先前在回避任务中所显示的，西咪替丁（1000纳克/大鼠）加异丙嗪（1000纳克/大鼠）的组合可阻断组胺在习惯化任务中的作用，但单独使用每种药物则无此效果。脑室内注射肥大细胞组胺释放剂48/80（0.1至100微克/大鼠）并未产生组胺的这种作用。目前的研究结果表明，组胺的记忆促进作用可能在各种任务中普遍存在，并且48/80可释放的、推测为肥大细胞的内源性组胺可能不参与记忆调节。
