de Almeida M A, Izquierdo I
Arch Int Pharmacodyn Ther. 1986 Oct;283(2):193-8.
The immediate posttraining intracerebroventricular administration of histamine (1 or 10, but not 0.1 or 100, ng/rat) facilitated retention test performance of step-down inhibitory avoidance behavior measured 24 hr later, in rats. The effect was antagonized by the simultaneous administration of both promethazine (1000 ng/rat) and cimetidine (1000 ng/rat), but not by either promethazine or cimetidine given alone. The antagonists had no effect of their own on behavior. The findings show that histamine has an extraordinarily powerful effect on memory processes, but do not necessarily suggest that this substance has a physiological role in memory modulation.
训练后立即向大鼠脑室内注射组胺（1或10纳克/大鼠，但不是0.1或100纳克/大鼠），可促进24小时后测量的大鼠一步下降抑制性回避行为的记忆测试表现。同时注射异丙嗪（1000纳克/大鼠）和西咪替丁（1000纳克/大鼠）可拮抗该效应，但单独注射异丙嗪或西咪替丁则无此作用。拮抗剂本身对行为没有影响。这些发现表明组胺对记忆过程具有极其强大的作用，但不一定表明该物质在记忆调节中具有生理作用。
