Hospital Israelita Albert Einstein, São Paulo, Brazil.
Hospital Sírio Libanês, São Paulo, Brazil.
Vox Sang. 2021 May;116(5):557-563. doi: 10.1111/vox.13044. Epub 2021 Mar 2.
Blood groups and anti-A isohemagglutinin may be involved in susceptibility to SARS-CoV-2 infection.
We retrospectively studied 268 COVID-19 convalescent plasma donors and 162 COVID-19 inpatients (total 430 subjects, confirmed by RT-PCR) and 2,212 healthy volunteer first-time blood donors as a control group. These were further divided into two groups: those with anti-A (blood types O and B) and those without it (types A and AB). Titres of nucleoproteins, and neutralizing SARS-CoV-2 antibody were measured in the convalescent plasma donors and inpatients. Multivariate logistic regression and non-parametric tests were applied.
Persons having types O or B showed less infection prevalence than those of types A or AB (OR = 0·62, 95% CI 0·50-0·78; P < 0·001), but there was no difference when COVID-19 inpatients were analysed. Immunoglobulins M, G and A were lower in COVID-19 subjects of types O or B group than those of A or AB (0·16 vs. 0·19; P = 0·03, 2·11 vs. 2·55; P = 0·02, 0·23 vs. 0·32; P = 0·03, respectively).
In this retrospective cohort, COVID-19 individuals were less likely to belong to blood types O and B, and also had lower SARS-CoV-2 antibody titres than A and AB individuals. COVID-19 severity did not associate with the blood groups.
血型和抗 A 同种血凝素可能与 SARS-CoV-2 感染易感性有关。
我们回顾性研究了 268 名 COVID-19 恢复期血浆捐献者和 162 名 COVID-19 住院患者（共 430 名患者，经 RT-PCR 确诊）以及 2212 名健康志愿者初次献血者作为对照组。这些患者进一步分为两组：有抗 A（血型 O 和 B）和无抗 A（血型 A 和 AB）。在恢复期血浆捐献者和住院患者中测量核蛋白和中和 SARS-CoV-2 抗体的滴度。应用多变量逻辑回归和非参数检验。
与 A 或 AB 血型相比，O 或 B 血型的人感染率较低（OR=0.62，95%CI 0.50-0.78；P<0.001），但 COVID-19 住院患者分析时无差异。与 A 或 AB 血型组相比，O 或 B 血型组 COVID-19 患者的免疫球蛋白 M、G 和 A 较低（0.16 比 0.19；P=0.03，2.11 比 2.55；P=0.02，0.23 比 0.32；P=0.03）。
在这项回顾性队列研究中，COVID-19 患者更不可能属于 O 和 B 血型，并且 SARS-CoV-2 抗体滴度也低于 A 和 AB 血型患者。COVID-19 的严重程度与血型无关。
