Bingen E, Lambert-Zechovsky N, Beaufils F, Mercier J C, Cohen R, Roze J C
Laboratoire de Bactériologie, Hôpital Bretonneau, Paris.
Arch Fr Pediatr. 1988 Jan;45(1):61-4.
Rapid bactericidal effect is essential for therapy of severe Staphylococcus aureus infections in children. The in vitro activity of clinically achievable levels of vancomycin and its combinations with gentamicin, amikacin and rifampin plus amikacin was studied with the time-kill curve method at 2.5, 4, 6, 24 and 48 hours against 20 strains of Staphylococcus aureus isolated from children with severe staphylococcal infection. Vancomycin alone exerted a bactericidal effect at 48 hours. However, with the combinations vancomycin plus gentamicin, vancomycin plus amikacin and vancomycin plus amikacin plus rifampin a bactericidal effect was respectively observed at 24, 6 and 4 hours. Most rapid killing was achieved with vancomycin plus rifampin plus amikacin. Thus this antibiotic combination seems the most appropriate for initial treatment of severe staphylococcal infections in children.
快速杀菌作用对于儿童严重金黄色葡萄球菌感染的治疗至关重要。采用时间杀菌曲线法，研究了临床可达到水平的万古霉素及其与庆大霉素、阿米卡星的组合以及利福平加阿米卡星在2.5、4、6、24和48小时对从患有严重葡萄球菌感染的儿童中分离出的20株金黄色葡萄球菌的体外活性。单独使用万古霉素在48小时时发挥杀菌作用。然而，万古霉素加庆大霉素、万古霉素加阿米卡星以及万古霉素加阿米卡星加利福平的组合分别在24、6和4小时时观察到杀菌作用。万古霉素加利福平加阿米卡星实现了最快的杀菌效果。因此，这种抗生素组合似乎最适合儿童严重葡萄球菌感染的初始治疗。
