McGurk S R, Levin E D, Butcher L L
Department of Psychology, University of California, Los Angeles 90024-1563.
Behav Neural Biol. 1988 Mar;49(2):234-9. doi: 10.1016/s0163-1047(88)90539-0.
Although acetylcholine and dopamine are believed to play complementary roles in motor function, a comparable neurochemical interaction has not been established for cognitive function. The muscarinic receptor blocker scopolamine and the dopaminergic antagonist haloperidol have been found to impair choice accuracy of rats in the radial-arm maze. In the present study, low doses of these two drugs were administered intraperitoneally either alone or in combination to rats trained on a working memory task (food reward) in an eight-arm radial maze. Scopolamine, 0.125 mg/kg, produced a significant decrease in choice accuracy (i.e., arm entries until an error). Haloperidol, 0.0625 mg/kg, did not cause a significant decrease in accuracy, but there was a trend in that direction. The combination of haloperidol with scopolamine attenuated significantly the amnestic effect of scopolamine. These results suggest that, like motor behavior, cognitive function may be influenced by the balance between acetylcholine and dopamine.
尽管人们认为乙酰胆碱和多巴胺在运动功能中发挥着互补作用，但尚未确定它们在认知功能方面存在类似的神经化学相互作用。已发现毒蕈碱受体阻滞剂东莨菪碱和多巴胺能拮抗剂氟哌啶醇会损害大鼠在放射状臂迷宫中的选择准确性。在本研究中，将低剂量的这两种药物单独或联合腹腔注射给在八臂放射状迷宫中接受工作记忆任务（食物奖励）训练的大鼠。0.125mg/kg的东莨菪碱使选择准确性显著降低（即直到出现错误的臂进入次数）。0.0625mg/kg的氟哌啶醇未导致准确性显著降低，但有朝该方向发展的趋势。氟哌啶醇与东莨菪碱联合使用可显著减弱东莨菪碱的遗忘作用。这些结果表明，与运动行为一样，认知功能可能受乙酰胆碱和多巴胺之间平衡的影响。
