与肠道微生物群介导的免疫检查点抑制剂反应调节相关的治疗干预措施及机制。
Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint inhibitor responses.
作者信息
Wong Matthew K, Barbulescu Philip, Coburn Bryan, Reguera-Nuñez Elaine
机构信息
Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Department of Medicine, Division of Infectious Diseases, University Health Network, Toronto, M5G 0A3, Canada.
出版信息
Microbes Infect. 2021 Jul-Aug;23(6-7):104804. doi: 10.1016/j.micinf.2021.104804. Epub 2021 Feb 27.
The link between the gut microbiome and responsiveness to immune checkpoint inhibitor (ICI) therapy is now well established. New therapeutic opportunities exploiting this relationship are being developed with the goal of augmenting ICI efficacy. In this review, we summarize the foundational research establishing these interactions and discuss the mechanisms and novel therapeutic options associated with this gut microbiome-ICI connection.
肠道微生物群与免疫检查点抑制剂（ICI）治疗反应性之间的联系现已得到充分证实。利用这种关系的新治疗机会正在开发中，目的是提高ICI的疗效。在这篇综述中，我们总结了确立这些相互作用的基础研究，并讨论了与这种肠道微生物群-ICI联系相关的机制和新型治疗选择。
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