Sports Medicine Research Center, Keio University, Yokohama 223-8521, Japan.
Nutrients. 2021 Feb 26;13(3):753. doi: 10.3390/nu13030753.
Aging patients with type 2 diabetes (T2DM) have a high risk of frailty and disability. This narrative review summarizes the current findings and future tasks regarding the following issues: (1) the optimum body mass index (BMI) target for patients with T2DM, (2) energy expenditure and requirements of patients with T2DM, and (3) the significance of low-intensity physical activity (LPA) as a key determinant of total energy expenditure (TEE) among the older population. While weight reduction is associated with an improvement in glycemic control, an increased risk of mortality as well as disability related to unhealthy BMI must also be considered, especially in older patients. The optimum BMI range and energy requirements for maintaining a healthy BMI should be identified. Limited evidence has shown that the TEE measured using the doubly labeled water method in patients with T2DM did not differ from that of subjects without diabetes, suggesting that the energy requirement data of subjects without diabetes may be applicable to these populations. LPA is one of the determinants of variability in the energy requirements of older patients with T2DM, and the beneficial effects of increasing LPA on nutritional intake and frailty prevention should be investigated further.
患有 2 型糖尿病(T2DM)的老年患者有发生衰弱和残疾的高风险。本综述总结了目前关于以下问题的研究结果和未来任务:(1)T2DM 患者的最佳体重指数(BMI)目标,(2)T2DM 患者的能量消耗和需求,以及(3)低强度体力活动(LPA)作为老年人总能量消耗(TEE)的关键决定因素的意义。虽然体重减轻与血糖控制的改善有关,但也必须考虑到因 BMI 不健康而增加的死亡率和与残疾相关的风险,尤其是在老年患者中。应确定维持健康 BMI 的最佳 BMI 范围和能量需求。有限的证据表明,使用双标记水法测量的 T2DM 患者的 TEE 与无糖尿病患者的 TEE 无差异,这表明无糖尿病患者的能量需求数据可能适用于这些人群。LPA 是影响 T2DM 老年患者能量需求变化的决定因素之一,应进一步研究增加 LPA 对营养摄入和预防虚弱的有益影响。