Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy.
Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy.
Biomolecules. 2021 Feb 26;11(3):356. doi: 10.3390/biom11030356.
In recent years, the interest in oxygen-ozone (OO) therapy application has considerably increased in the field of rehabilitation. Despite its widespread use in common clinical practice, the biochemical effects of OO are still far from being understood, although its chemical properties seem to play a pivotal role in exerting its positive effects on different pathological conditions. Indeed, the effectiveness of OO therapy might be partly due to the moderate oxidative stress produced by O interactions with biological components. OO therapy is widely used as an adjuvant therapeutic option in several pathological conditions characterized by chronic inflammatory processes and immune over-activation, and most musculoskeletal disorders share these pathophysiological processes. The present comprehensive review depicts the state-of-the-art on the mechanisms of action, safety and effectiveness of OO therapy in the complex scenario of the management of musculoskeletal disorders. Taken together, our findings suggest that OO therapy seems to reduce pain and improve functioning in patients affected by low back pain and knee osteoarthritis, as reported by several studies in the literature. However, to date, further studies are warranted to clearly investigate the therapeutic effects of this promising therapy on other musculoskeletal disorders in the field of rehabilitation.
近年来，康复领域对氧气-臭氧（OO）治疗应用的兴趣显著增加。尽管 OO 在普通临床实践中广泛应用，但 OO 的生化作用仍远未被理解，尽管其化学性质似乎在对不同病理状况产生积极影响方面发挥着关键作用。事实上，OO 治疗的有效性可能部分归因于 O 与生物成分相互作用产生的适度氧化应激。OO 治疗被广泛用作几种以慢性炎症过程和免疫过度激活为特征的病理状况的辅助治疗选择，大多数肌肉骨骼疾病都具有这些病理生理过程。本综述全面描述了 OO 治疗在肌肉骨骼疾病管理的复杂情况下的作用机制、安全性和有效性的最新进展。总的来说，我们的研究结果表明，正如文献中的几项研究报道的那样，OO 治疗似乎可以减轻腰痛和膝骨关节炎患者的疼痛并改善其功能。然而，迄今为止，还需要进一步的研究来明确调查这种有前途的治疗方法对康复领域中其他肌肉骨骼疾病的治疗效果。
