Ronconi Gianpaolo, Mariantonietta Ariani, Codazza Sefora, Cutaia Alberto, Zeni Alessandra, Forastiere Lucia, Ferriero Giorgio, Ferrara Paola Emilia
Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00168 Rome, Italy.
Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Department of Geriatrics, Orthopedics and Rheumatology, L.go A. Gemelli 8, 00168 Rome, Italy.
J Clin Med. 2025 Apr 3;14(7):2452. doi: 10.3390/jcm14072452.
Ozone therapy is used for its immunomodulatory, antioxidant, and analgesic properties in several fields. It can be useful in the rehabilitation of musculoskeletal disorders. Studies showed that O-O therapy can reduce pain and improve functioning in patients affected by low back pain and knee osteoarthritis. Only a few studies have been published about the efficacy of this treatment in upper limb disease. : The aim of this study is to investigate the use of ozone therapy in upper limb pathologies, evaluating its quantity, quality, and reported results in upper limb musculoskeletal disease, supraspinatus tendinopathy, shoulder impingement, adhesive capsulitis, chronic epicondylitis, and carpal tunnel syndrome. O-O reduces inflammation by stimulating anti-inflammatory cytokines and inactivating pro-inflammatory molecules, relieves pain by interacting with pain receptors and improving blood circulation, promotes the regeneration of damaged tissues by stimulating growth factors and improving vascularization, and, finally, activates endogenous antioxidant defense systems by protecting cells from oxidative damage. : A comprehensive search was conducted on PubMed and Scopus using the following MeSH terms: ozone therapy, infiltration joint, musculoskeletal disease, rehabilitation, upper limb, shoulder, wrist, hand, elbow, including English papers published in the last five years. : Five papers have been selected: four randomized controlled trials and one retrospective cohort study. The RCTs compared the effectiveness of intra-articular ozone injection with steroid injection alone or with other conservative treatments in shoulder diseases; one paper studied the effectiveness of ozone injection and orthoses in carpal tunnel syndrome compared to orthoses alone; one paper used ozone injections compared with steroid injection in patients with chronic lateral epicondylitis. A total of 218 patients were studied in these trials. : Ozone treatment seemed to improve pain and function as well as other therapies in upper limb musculoskeletal disease. However, the trials' protocols and the upper limb areas treated are different. Further studies are needed to define the effectiveness of ozone therapy in upper limb diseases in rehabilitation fields.
臭氧疗法因其免疫调节、抗氧化和镇痛特性而在多个领域得到应用。它在肌肉骨骼疾病的康复中可能有用。研究表明，臭氧-氧气疗法可减轻受腰痛和膝骨关节炎影响患者的疼痛并改善其功能。关于这种治疗在上肢疾病中的疗效，仅有少数研究发表。本研究的目的是调查臭氧疗法在上肢疾病中的应用，评估其在治疗上肢肌肉骨骼疾病、冈上肌腱病、肩部撞击症、粘连性囊炎、慢性肱骨外上髁炎和腕管综合征方面的用量、质量及报告结果。臭氧-氧气通过刺激抗炎细胞因子和使促炎分子失活来减轻炎症，通过与疼痛感受器相互作用并改善血液循环来缓解疼痛，通过刺激生长因子和改善血管形成来促进受损组织的再生，最后通过保护细胞免受氧化损伤来激活内源性抗氧化防御系统。使用以下医学主题词在PubMed和Scopus上进行了全面检索：臭氧疗法、关节内注射、肌肉骨骼疾病、康复、上肢、肩部、腕部、手部、肘部，检索范围包括过去五年发表的英文论文。共筛选出五篇论文：四项随机对照试验和一项回顾性队列研究。随机对照试验比较了关节内注射臭氧与单独注射类固醇或与其他保守治疗在肩部疾病中的有效性；一篇论文研究了臭氧注射和矫形器与单独使用矫形器相比在腕管综合征中的有效性；一篇论文比较了臭氧注射与类固醇注射在慢性外侧肱骨外上髁炎患者中的有效性。这些试验共研究了218名患者。臭氧治疗似乎与其他疗法一样能改善上肢肌肉骨骼疾病中的疼痛和功能。然而，试验方案和所治疗的上肢区域各不相同。需要进一步研究来确定臭氧疗法在康复领域上肢疾病中的有效性。
