Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Stem Cell Res Ther. 2021;16(8):980-993. doi: 10.2174/1574888X16666210302151823.
Mesenchymal stem/stromal cells (MSCs) are adult multipotent cells with self-renewal potential and the ability to differentiate into specialized cells. MSCs home in various tissues and can be isolated using simple methods. Because of this feasibility in the isolation and culture of MSCs in vitro, many scientists have focused on the therapeutic applications of MSCs for various diseases and conditions. The selection of the tissue source to obtain MSCs mainly depends on the availability of the tissue, the patient's health status, as well as the expertise of the researcher. However, some studies indicate that MSCs derived from different tissue sources are not the same and possess different regenerative capacities. Therefore, in this review, we have collected and summarized the results from studies that have performed head-to-head comparisons between MSCs isolated from different tissues. Despite the assessment method discrepancy between studies, results from these studies reveal that MSCs derived from different tissue sources are not the same. Some such as umbilical cord-derived MSCs and menstrual blood-derived MSCs were identified with robust angiogenic potentials. However, cord blood-derived MSCs possessed a strong cartilage repair capacity. Further investigations are required to establish certain capabilities for MSCs derived from a particular tissue origin. Nevertheless, it is recommended to consider the possibility of functional variations between MSCs isolated from distinct tissue origins when applying MSCs in clinics.
间充质干细胞（MSCs）是具有自我更新潜力和分化为特定细胞能力的成体多能细胞。MSCs 归巢于各种组织，并可采用简单的方法进行分离。由于在体外分离和培养 MSCs 的可行性，许多科学家专注于 MSC 对各种疾病和病症的治疗应用。MSC 组织来源的选择主要取决于组织的可用性、患者的健康状况以及研究人员的专业知识。然而，一些研究表明，源自不同组织来源的 MSCs 并不相同，并且具有不同的再生能力。因此，在这篇综述中，我们收集并总结了来自不同组织来源的 MSC 进行头对头比较的研究结果。尽管研究之间的评估方法存在差异，但这些研究的结果表明，源自不同组织来源的 MSCs 并不相同。一些组织来源的 MSCs，如脐带和月经血来源的 MSC，被鉴定具有强大的血管生成潜力。然而，脐血来源的 MSC 具有很强的软骨修复能力。需要进一步的研究来确定特定组织来源的 MSC 具有某些能力。尽管如此，当将 MSCs 应用于临床时，建议考虑源自不同组织来源的 MSC 之间功能变化的可能性。
