Ogbodo John O, Agbo Chinazom P, Njoku Ugochi O, Ogugofor Martins O, Egba Simeon I, Ihim Stella A, Echezona Adaeze C, Brendan Kenneth C, Upaganlawar Aman B, Upasani Chandrashekhar D
Department of Science Laboratory Technology, University of Nigeria, Nsukka, Nigeria.
Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria.
Curr Aging Sci. 2022;15(1):2-25. doi: 10.2174/1874609814666210302085232.
Alzheimer's Disease (AD) is the most common cause of dementia. Genetics, excessive exposure to environmental pollutants, as well as unhealthy lifestyle practices are often linked to the development of AD. No therapeutic approach has achieved complete success in treating AD; however, early detection and management with appropriate drugs are key to improving prognosis.
The pathogenesis of AD was extensively discussed in order to understand the reasons for the interventions suggested. The interventions reviewed include the use of different therapeutic agents and approaches, gene therapy, adherence to healthy dietary plans (Mediterranean diet, Okinawan diet and MIND diet), as well as the use of medicinal plants. The potential of nanotechnology as a multidisciplinary and interdisciplinary approach in the design of nano-formulations of AD drugs and the use of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as theranostic tools for early detection of Alzheimer's disease were also discussed.
阿尔茨海默病（AD）是痴呆最常见的病因。遗传因素、过度暴露于环境污染物以及不健康的生活方式常常与AD的发病相关。目前尚无治疗方法能在治疗AD方面取得完全成功；然而，早期检测并使用适当药物进行管理是改善预后的关键。
为了理解所建议干预措施的原因，对AD的发病机制进行了广泛讨论。所审查的干预措施包括使用不同的治疗药物和方法、基因治疗、坚持健康饮食计划（地中海饮食、冲绳饮食和MIND饮食）以及使用药用植物。还讨论了纳米技术作为一种多学科和跨学科方法在设计AD药物纳米制剂方面的潜力，以及使用超顺磁性氧化铁纳米颗粒（SPIONs）作为早期检测阿尔茨海默病的诊疗工具的潜力。
