Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.
Centre de Recherche des Cordeliers, Equipe labellisée Par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.
Aging (Albany NY). 2021 Mar 2;13(5):6375-6405. doi: 10.18632/aging.202739.
The presence of (Akk) in the human gut is associated with good health, leanness and fitness. Mouse experimentation has demonstrated positive effects for Akk, which counteracts aging, mediates antiobesity and antidiabetic effects, dampens inflammation and improves anticancer immunosurveillance. Clinical trials have confirmed antidiabetic effects for Akk. Here, we investigated the time-dependent effects of oral administration of Akk (which was live or pasteurized) and other bacteria to mice on the metabolome of the ileum, colon, liver and blood plasma. Metabolomics was performed by a combination of chromatographic and mass spectrometric methods, yielding a total of 1.637.227 measurements. Akk had major effects on metabolism, causing an increase in spermidine and other polyamines in the gut and in the liver. Pasteurized Akk (Akk-past) was more efficient than live Akk in elevating the intestinal concentrations of polyamines, short-chain fatty acids, 2-hydroxybutyrate, as well multiple bile acids, which also increased in the circulation. All these metabolites have previously been associated with human health, providing a biochemical basis for the beneficial effects of Akk.
(Akk) 在人类肠道中的存在与健康、苗条和健康有关。老鼠实验表明 Akk 具有积极作用，可以对抗衰老、介导抗肥胖和抗糖尿病作用、抑制炎症和改善抗肿瘤免疫监视。临床试验证实了 Akk 的抗糖尿病作用。在这里，我们研究了口服 Akk（活菌或巴氏杀菌菌）和其他细菌对小鼠回肠、结肠、肝脏和血浆代谢组的时间依赖性影响。代谢组学通过色谱和质谱方法的组合进行，共获得 1637227 个测量值。 Akk 对代谢有重大影响，导致肠道和肝脏中多胺（如亚精胺）和其他多胺的增加。巴氏杀菌 Akk（Akk-past）比活菌 Akk 更有效地提高肠道中多胺、短链脂肪酸、2-羟基丁酸以及多种胆汁酸的浓度，这些物质也在循环中增加。所有这些代谢物以前都与人类健康有关，为 Akk 的有益作用提供了生化基础。
