Gyriki Despoina, Nikolaidis Christos G, Bezirtzoglou Eugenia, Voidarou Chrysa, Stavropoulou Elisavet, Tsigalou Christina
Master Program in "Food, Nutrition and Microbiome", Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Internal Medicine Department, Vostaneio-General Hospital of Mytilene, Mytilene, Greece.
Front Aging. 2025 May 14;6:1452917. doi: 10.3389/fragi.2025.1452917. eCollection 2025.
The human microbiota, a complex ecosystem of microorganisms inhabiting various body sites, particularly the gut, plays a crucial role in maintaining health and influencing disease susceptibility. Dysbiosis, characterized by alterations in microbial composition and diversity, has been implicated in numerous diseases, including those associated with aging. This review examines the complex relationship between gut microbiota and aging, highlighting the age-associated gut microbiota alterations, the factors contributing to these changes, the links between microbiota and age-related diseases, and the potential of interventions targeting the microbiome to extend lifespan and improve health outcomes in the elderly. Further research is needed to unravel the intricate mechanisms underlying the interplay between the microbiome and aging, paving the way for innovative strategies to promote healthy aging.
人类微生物群是一个栖息在身体各个部位（尤其是肠道）的复杂微生物生态系统，在维持健康和影响疾病易感性方面发挥着关键作用。以微生物组成和多样性改变为特征的生态失调与多种疾病有关，包括与衰老相关的疾病。本综述探讨了肠道微生物群与衰老之间的复杂关系，重点介绍了与年龄相关的肠道微生物群变化、导致这些变化的因素、微生物群与年龄相关疾病之间的联系，以及针对微生物组的干预措施在延长老年人寿命和改善健康结果方面的潜力。需要进一步研究以揭示微生物组与衰老之间相互作用的复杂机制，为促进健康衰老的创新策略铺平道路。
