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LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury.

作者信息

Zhan Xueqin, Cui Rui, Geng Xinwei, Li Jiaqian, Zhou Yunlian, He Lulu, Cao Chao, Zhang Chao, Chen Zhimin, Ying Songmin

机构信息

Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, China.

International Institutes of Medicine, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.

出版信息

Signal Transduct Target Ther. 2021 Mar 3;6(1):103. doi: 10.1038/s41392-021-00494-7.

DOI:10.1038/s41392-021-00494-7
PMID:33654053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7925566/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f315/7925566/e5f6a0d1df3f/41392_2021_494_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f315/7925566/e5f6a0d1df3f/41392_2021_494_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f315/7925566/e5f6a0d1df3f/41392_2021_494_Fig1_HTML.jpg

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2
The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation.DNA 修复核酸酶 MRE11A 作为一种线粒体保护因子,可防止 T 细胞焦亡和组织炎症。
Cell Metab. 2019 Sep 3;30(3):477-492.e6. doi: 10.1016/j.cmet.2019.06.016. Epub 2019 Jul 18.
3
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.
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Stem Cells Transl Med. 2024 Aug 16;13(8):826-841. doi: 10.1093/stcltm/szae042.
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Mitochondrial E3 ligase MARCH5 is a safeguard against DNA-PKcs-mediated immune signaling in mitochondria-damaged cells.线粒体 E3 连接酶 MARCH5 是线粒体受损细胞中 DNA-PKcs 介导的免疫信号的保护机制。
Cell Death Dis. 2023 Dec 1;14(12):788. doi: 10.1038/s41419-023-06315-9.
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Nat Commun. 2023 Oct 12;14(1):6416. doi: 10.1038/s41467-023-42187-5.
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