National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.
Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P.R. China.
Nat Commun. 2021 Mar 2;12(1):1383. doi: 10.1038/s41467-021-21503-x.
In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China. From January to April 2020, 38,144 healthy blood donors in the three cities were tested for total antibody against SARS-CoV-2 followed by pseudotype SARS-CoV-2 neutralization tests, IgG, and IgM antibody testing. Finally, a total of 398 donors were confirmed positive. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18-60 year-old adults (18-65 year-old in Shenzhen) was 2.66% (95% CI: 2.24%-3.07%) in Wuhan, 0.033% (95% CI: 0.0029%-0.267%) in Shenzhen, and 0.0028% (95% CI: 0.0001%-0.158%) in Shijiazhuang, respectively. Female sex and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among blood donors in Wuhan. As most of the population of China remained uninfected during the early wave of the COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.
在这项研究中，我们调查了中国武汉、深圳和石家庄三个城市献血者中 SARS-CoV-2 抗体的血清流行率。2020 年 1 月至 4 月，对三个城市的 38144 名健康献血者进行了 SARS-CoV-2 总抗体检测，随后进行了假型 SARS-CoV-2 中和试验、IgG 和 IgM 抗体检测。最终，共有 398 名献血者被确认为阳性。在年龄和性别标准化后，18-60 岁成年人（深圳为 18-65 岁）的 SARS-CoV-2 血清流行率在武汉为 2.66%（95%CI：2.24%-3.07%），在深圳为 0.033%（95%CI：0.0029%-0.267%），在石家庄为 0.0028%（95%CI：0.0001%-0.158%）。在武汉，女性和高龄是献血者 SARS-CoV-2 血清阳性的独立危险因素。由于中国大部分人口在 COVID-19 大流行的早期阶段没有感染，因此在广泛使用疫苗之前，仍然需要采取有效的公共卫生措施来阻止病毒传播。
