Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
Physical Examination Centre, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan University, Wuhan, Hubei, China.
Clin Microbiol Infect. 2021 Feb;27(2):253-257. doi: 10.1016/j.cmi.2020.09.044. Epub 2020 Oct 7.
The outbreak of the 2019 coronavirus disease (COVID-19) pandemic in Wuhan, China, has subsided after being hard hit by the disease and subsequent city lockdown. Information on the number of people involved in Wuhan is still inadequate. This study aimed to describe the screening results of 61 437 community members in Wuchang District, Wuhan.
In mid-May 2020, Wuhan launched a population-scale city-wide SARS-CoV-2 testing campaign, which aimed to perform nucleic acid and viral antibody testing for citizens in Wuhan. Here we show the screening results of cluster sampling of 61 437 residents in Wuchang District, Wuhan, China.
A total of 1470 (2.39%, 95% CI 2.27-2.52) individuals were detected positive for at least one antiviral antibody. Among the positive individuals, 324 (0.53%, 95% CI 0.47-0.59) and 1200 (1.95%, 95% CI 1.85-2.07) were positive for immunoglobulin IgM and IgG, respectively, and 54 (0.08%, 95% CI 0.07-0.12) were positive for both antibodies. The positive rate of female carriers of antibodies was higher than those of male counterparts (male-to-female ratio of 0.75), especially in elderly citizens (ratio of 0.18 in 90+ age subgroup), indicating a sexual discrepancy in seroprevalence. In addition, viral nucleic acid detection using real-time PCR had showed 8 (0.013%, 95% CI 0.006-0.026) asymptomatic virus carriers.
The seroprevalence of SARS-CoV-2 in Wuhan was low. Most Wuhan residents are still susceptible to this virus. Precautions, such as wearing mask, frequent hand hygiene and proper social distance, are necessary before an effective vaccine or antiviral treatments are available.
中国武汉市遭受 2019 年冠状病毒病（COVID-19）大流行的重创后，疫情已得到控制。关于武汉涉及人数的信息仍然不足。本研究旨在描述武汉市武昌区 61437 名社区居民的筛查结果。
2020 年 5 月中旬，武汉启动了一项全市范围内的人群规模的 SARS-CoV-2 检测运动，旨在对武汉市民进行核酸和病毒抗体检测。在这里，我们展示了中国武汉市武昌区 61437 名居民的聚类抽样筛查结果。
共有 1470 人（2.39%，95%置信区间 2.27-2.52）至少有一种抗病毒抗体检测呈阳性。在阳性个体中，324 人（0.53%，95%置信区间 0.47-0.59）和 1200 人（1.95%，95%置信区间 1.85-2.07）的免疫球蛋白 IgM 和 IgG 呈阳性，54 人（0.08%，95%置信区间 0.07-0.12）两种抗体均呈阳性。女性抗体携带者的阳性率高于男性（男女性别比为 0.75），尤其是在老年居民中（90 岁以上年龄组的性别比为 0.18），表明血清流行率存在性别差异。此外，使用实时 PCR 的病毒核酸检测显示 8 例（0.013%，95%置信区间 0.006-0.026）无症状病毒携带者。
武汉市 SARS-CoV-2 的血清流行率较低。大多数武汉居民仍然容易感染这种病毒。在有有效疫苗或抗病毒治疗方法之前，有必要采取预防措施，如戴口罩、勤洗手和保持适当的社交距离。
