Carlton Morgan, Voisey Joanne, Parker Tony J, Punyadeera Chamindie, Cuttle Leila
Queensland University of Technology (QUT), Centre for Children's Burn and Trauma Research, Centre for Children's Health Research, South Brisbane, Queensland, Australia.
Queensland University of Technology (QUT), Faculty of Health, School of Biomedical Sciences, Brisbane, Queensland, Australia.
Burns Trauma. 2021 Feb 9;9:tkaa049. doi: 10.1093/burnst/tkaa049. eCollection 2021 Jan.
Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns. The objective of this review is to summarize the evidence supporting the use of biomarkers in children with burns. An extensive review of the literature was performed using PubMed. A total of 59 biomarkers were identified relating to burn presence, specifically relating to processes involved in inflammation, wound healing, growth and metabolism. In addition, biomarkers involved in the stress response cascade following a burn trauma were also identified. Although many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma, an understanding of burn biology is still lacking in children. We propose that future research in the field of children's burns should be conducted using broad screening methods for identifying potential biomarkers, examine the biological interactions of different biomarkers, utilize child-appropriate biological fluids such as urine or saliva, and include a range of different severity burns. Through further research, the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed, for the improvement of healing outcomes in paediatric burn patients.
评估烧伤的身体愈合情况以及心理影响的生物标志物对于小儿烧伤的有效治疗至关重要。本综述的目的是总结支持在烧伤儿童中使用生物标志物的证据。使用PubMed对文献进行了广泛综述。共鉴定出59种与烧伤存在相关的生物标志物，具体涉及炎症、伤口愈合、生长和代谢过程。此外，还鉴定出了烧伤创伤后应激反应级联中涉及的生物标志物。尽管已经鉴定出许多可能与烧伤相关的身体和心理创伤有关的生物标志物，但对儿童烧伤生物学的了解仍然不足。我们建议，未来儿童烧伤领域的研究应采用广泛的筛选方法来识别潜在的生物标志物，研究不同生物标志物之间的生物学相互作用，使用适合儿童的生物体液如尿液或唾液，并纳入一系列不同严重程度的烧伤病例。通过进一步研究，可能会充分了解对烧伤损伤的生物学反应，并开发出利用这些生物标志物的临床相关诊断测试和治疗方法，以改善小儿烧伤患者的愈合结果。
