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用于模拟特定条件下骨转移的骨培养阵列

Bone-in-culture Array to Model Bone Metastasis in Condition.

作者信息

Wang Hai, Zhang Xiang H-F

机构信息

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, United States.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.

出版信息

Bio Protoc. 2020 Jan 20;10(2):e3495. doi: 10.21769/BioProtoc.3495.

DOI:10.21769/BioProtoc.3495
PMID:33654726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7842296/
Abstract

Bone is the most frequently affected organ by metastases of breast cancer and prostate cancer. Our knowledge on bone metastasis is extremely limited due to the lack of potent and efficient experimental models. We developed the "Bone-In-Culture Array (BICA)" platform to model the bone colonization of cancer cells in cultures. The use of the BICA platform will facilitate in-depth mechanistic studies and high-throughput screening of drugs for bone metastasis.

摘要

骨骼是乳腺癌和前列腺癌转移最常累及的器官。由于缺乏有效且高效的实验模型，我们对骨转移的了解极为有限。我们开发了“培养骨阵列（BICA）”平台，用于在培养物中模拟癌细胞的骨定植。BICA平台的使用将有助于对骨转移进行深入的机制研究和高通量药物筛选。

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本文引用的文献

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The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability.成骨龛是骨微转移灶的钙库，并赋予其意料之外的治疗弱点。
Cancer Cell. 2018 Nov 12;34(5):823-839.e7. doi: 10.1016/j.ccell.2018.10.002.
2
A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries.经尾动脉注射癌细胞建立可靠的小鼠骨转移模型。
Nat Commun. 2018 Jul 30;9(1):2981. doi: 10.1038/s41467-018-05366-3.
3
Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies.骨培养芯片作为一种平台，用于模拟早期骨转移并发现抗转移治疗方法。
Nat Commun. 2017 Apr 21;8:15045. doi: 10.1038/ncomms15045.
4
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis.髂内动脉注射用于高效、选择性地建立微观骨转移模型
J Vis Exp. 2016 Sep 26(115):53982. doi: 10.3791/53982.
5
In vitro and in vivo model systems used in prostate cancer research.前列腺癌研究中使用的体外和体内模型系统。
J Biol Methods. 2015;2(1). doi: 10.14440/jbm.2015.63.
6
Animal Models of Bone Metastasis.骨转移的动物模型
Vet Pathol. 2015 Sep;52(5):827-41. doi: 10.1177/0300985815586223. Epub 2015 May 28.
7
The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.成骨龛促进播散性乳腺癌细胞早期阶段的骨定植。
Cancer Cell. 2015 Feb 9;27(2):193-210. doi: 10.1016/j.ccell.2014.11.017. Epub 2015 Jan 15.
8
In vitro microenvironments to study breast cancer bone colonisation.体外微环境研究乳腺癌骨转移。
Adv Drug Deliv Rev. 2014 Dec 15;79-80:135-44. doi: 10.1016/j.addr.2014.10.014. Epub 2014 Oct 23.
9
Rat models of bone metastases.骨转移的大鼠模型
Clin Exp Metastasis. 2005;22(8):605-14. doi: 10.1007/s10585-006-9002-5. Epub 2006 May 3.
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