Drosos A A, Andonopoulos A P, Costopoulos J S, Papadimitriou C S, Moutsopoulos H M
Department of Medicine, University of Ioannina, Greece.
Br J Rheumatol. 1988 Apr;27(2):123-7. doi: 10.1093/rheumatology/27.2.123.
Sixty-two elderly apparently healthy volunteers, inmates of a public nursing home, were examined for evidence of primary Sjögren's syndrome (pSS). Evaluation included a specific questionnaire for subjective xerophthalmia and xerostomia, slit-lamp eye examination after rose Bengal staining. Schirmer's I test, stimulated parotid flow measurement, testing of sera for autoantibodies and labial minor salivary gland biopsy. A greater than or equal to 2+ lip biopsy score on Tarpley's scale was a sine qua non for the diagnosis of Sjögren's syndrome. Labial salivary gland (LSG) biopsy revealed fibrosis and/or fatty infiltration in the majority of the individuals, related to ageing. However, four people had a lip biopsy score of greater than or equal to 2+, which, supplemented by other objective criteria, classified three of them as having pSS. Another four had an LSG biopsy score of 1+, and although they fulfilled other objective criteria, they could not be characterized as pSS. All these individuals were completely asymptomatic, and none of them had anti-Ro(SSA) or anti-La(SSB) autoantibodies. The present study suggests that pSS in elderly people in elderly people is subclinical, benign and relatively common.
对一家公立养老院的62名表面健康的老年志愿者进行了原发性干燥综合征（pSS）检查。评估内容包括一份关于主观干眼症和口干症的特定问卷、孟加拉玫瑰红染色后的裂隙灯眼部检查、施密特I试验、刺激腮腺流量测量、血清自身抗体检测以及唇小唾液腺活检。按照塔尔普利量表，唇活检评分大于或等于2+是诊断干燥综合征的必要条件。唇唾液腺（LSG）活检显示，大多数人存在纤维化和/或脂肪浸润，这与衰老有关。然而，有4人唇活检评分大于或等于2+，结合其他客观标准，其中3人被归类为患有pSS。另外4人LSG活检评分为1+，尽管他们符合其他客观标准，但不能被认定为pSS。所有这些人都完全没有症状，且均无抗Ro(SSA)或抗La(SSB)自身抗体。本研究表明，老年人中的pSS是亚临床的、良性的且相对常见。
