Bierman H R, Faith M R, Stewart M E
Institute for Cancer and Blood Research, Beverly Hills, California 90211.
Cancer Invest. 1988;6(1):15-27. doi: 10.3109/07357908809077025.
Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and horizontal ulnar loops. A fifth print, the angled radial loop, was found to be of borderline importance as an independent predictor of breast cancer. Of 200 patients in the case group, 27 had one or more accidental prints, 58 had one or more transitionals, 34 had one or more horizontal ulnar loops, and 93 had one or more angled ulnar loop patterns. In 138 control subjects there were 2 with accidental patterns, 21 with one or more transitionals, 6 with horizontal ulnar loops, and 16 with one or more angled ulnar loops. In addition, there appeared to be a gradient of risk; a woman with one type of suspicious print is at higher risk of breast cancer than a woman with none, and two suspicious prints indicate a higher risk than does one. If these findings are confirmed, the prints described will represent a noninvasive anatomical marker of breast cancer risk.
对200名经组织学证实患有乳腺癌的女性(病例组)的指纹与138名无任何恶性疾病病史的女性(对照组)的指纹进行了比较。在分析的指纹图案中,有四种与乳腺癌显著相关:偶然纹、过渡纹、尺侧箕形纹和水平尺侧箕形纹。第五种指纹,即桡侧箕形纹,被发现作为乳腺癌的独立预测指标,其重要性处于临界水平。病例组的200名患者中,27人有一个或多个偶然纹,58人有一个或多个过渡纹,34人有一个或多个水平尺侧箕形纹,93人有一个或多个尺侧箕形纹。在138名对照受试者中,有2人有偶然纹,21人有一个或多个过渡纹,6人有水平尺侧箕形纹,16人有一个或多个尺侧箕形纹。此外,似乎存在风险梯度;有一类可疑指纹的女性患乳腺癌的风险高于没有可疑指纹的女性,两种可疑指纹表明的风险高于一种。如果这些发现得到证实,所描述的指纹将代表一种乳腺癌风险的非侵入性解剖学标志物。