ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093 Zürich, Switzerland.
J Am Chem Soc. 2021 Mar 17;143(10):3723-3728. doi: 10.1021/jacs.1c00529. Epub 2021 Mar 3.
We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis.
我们描述了一种芳基腈和芳基硫醚之间的新型功能基复分解反应。镍/dcype 催化体系对于实现这种完全可逆的转化至关重要，产率良好至优秀。此外，该反应无需氰化物和硫醇，具有高官能团容忍度和对商业分子后期衍生化的高效率。最后，合成应用证明了其在多步合成中的多功能性和实用性。
