辐射诱导的鼠伤寒沙门氏菌内毒素变化
Radiation induced alterations in the endotoxin of S. typhimurium.
作者信息
Nerkar D P, Govekar L G, Kumta U S, Sreenivasan A
出版信息
Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Sep;32(3):259-66. doi: 10.1080/09553007714550971.
PMID:336564
Abstract
The lipopolysaccharide (LPS) of S. typhimurium has been shown to be significantly detoxified after in vivo irradiation at 500 krad. Radiation is thus a useful method for converting endotoxin into toxoid. The structural alterations in the detoxified LPS are shown to be mainly in the lipid A molecule, resulting in the loss of beta-hydroxymyristic acid.
摘要
鼠伤寒沙门氏菌的脂多糖（LPS）已被证明在500千拉德的体内辐射后能显著解毒。因此，辐射是一种将内毒素转化为类毒素的有用方法。解毒后的LPS的结构改变主要表现在脂质A分子上，导致β-羟基肉豆蔻酸的丢失。
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