Egawa K, Yoshida M, Sakaino R, Kasai N
Microbiol Immunol. 1984;28(11):1181-90. doi: 10.1111/j.1348-0421.1984.tb00776.x.
The alteration of hepatic drug-metabolizing enzyme activities in mice given Salmonella endotoxin by single or multiple intraperitoneal injections was investigated. An essentially the same biphasic, early and late phase, endotoxin tolerance was observed in the animals receiving a single injection of endotoxin or repetitive daily injections. The results of reciprocal cross tolerance tests using lipopolysaccharide and free lipid A preparations derived from Salmonella minnesota, Salmonella typhimurium, E. coli, Pseudomonas aeruginosa, and Chromobacterium violaceum suggested that lipid A moiety plays an important role in the induction of early endotoxin tolerance to endotoxin response.
研究了通过单次或多次腹腔注射给予沙门氏菌内毒素的小鼠肝脏药物代谢酶活性的变化。在接受单次内毒素注射或每日重复注射的动物中，观察到基本相同的双相，即早期和晚期内毒素耐受性。使用来自明尼苏达沙门氏菌、鼠伤寒沙门氏菌、大肠杆菌、铜绿假单胞菌和紫色色杆菌的脂多糖和游离脂质A制剂进行的交叉耐受性试验结果表明，脂质A部分在对内毒素反应的早期内毒素耐受性诱导中起重要作用。
