Rioux-Darrieulat F, Parant M, Chedid L
J Infect Dis. 1978 Jan;137(1):7-13. doi: 10.1093/infdis/137.1.7.
Small amounts of bacterial lipopolysaccharides (LPS), usually extracted from smooth organisms, have previously been shown to interrupt pregnancy in mice. The findings reported here demonstrate that LPS obtained from rough bacterial strains were also abortifacient. Moreover, lipid A, which represents a common toxic structure of LPS in many species of gram-negative Enterobacteriaceae, had the same activity, whereas the nontoxic polysaccharide moiety did not affect pregnancy. Our data also showed that specific bacterial antisera raised in various animal species protected pregnant mice from the abortifacient effect of smooth or rough LPS, and that this activity disappeared after absorption of the antisera with homologous bacteria. Nevertheless, antibodies to lipid A protected pregnant female mice challenged with lipid A or even with LPS extracted from various organisms. Moreover, pregnant mice treated with both antiserum and an antiserotonin compound were protected more effectively against LPS-induced abortion than mice treated with either substance alone.
通常从光滑型生物体中提取的少量细菌脂多糖（LPS），此前已被证明可导致小鼠流产。此处报告的研究结果表明，从粗糙型细菌菌株中获得的LPS也具有堕胎作用。此外，脂质A是许多革兰氏阴性肠杆菌科细菌中LPS的常见毒性结构，具有相同的活性，而无毒的多糖部分则不影响妊娠。我们的数据还表明，在各种动物物种中产生的特异性细菌抗血清可保护怀孕小鼠免受光滑型或粗糙型LPS的堕胎作用，并且在用同源细菌吸收抗血清后，这种活性消失。然而，针对脂质A的抗体可保护用脂质A甚至用从各种生物体中提取的LPS攻击的怀孕雌性小鼠。此外，与单独用任何一种物质处理的小鼠相比，用抗血清和抗血清素化合物处理的怀孕小鼠对LPS诱导的流产具有更有效的保护作用。
