Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangdong Academy of Science, Guangzhou, Guangdong Province, China.
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, Guangdong Province, China.
PLoS Pathog. 2020 May 14;16(5):e1008421. doi: 10.1371/journal.ppat.1008421. eCollection 2020 May.
The outbreak of a novel corona Virus Disease 2019 (COVID-19) in the city of Wuhan, China has resulted in more than 1.7 million laboratory confirmed cases all over the world. Recent studies showed that SARS-CoV-2 was likely originated from bats, but its intermediate hosts are still largely unknown. In this study, we assembled the complete genome of a coronavirus identified in 3 sick Malayan pangolins. The molecular and phylogenetic analyses showed that this pangolin coronavirus (pangolin-CoV-2020) is genetically related to the SARS-CoV-2 as well as a group of bat coronaviruses but do not support the SARS-CoV-2 emerged directly from the pangolin-CoV-2020. Our study suggests that pangolins are natural hosts of Betacoronaviruses. Large surveillance of coronaviruses in pangolins could improve our understanding of the spectrum of coronaviruses in pangolins. In addition to conservation of wildlife, minimizing the exposures of humans to wildlife will be important to reduce the spillover risks of coronaviruses from wild animals to humans.
中国武汉市爆发的新型冠状病毒病 2019（COVID-19）已导致全球超过 170 万例实验室确诊病例。最近的研究表明，SARS-CoV-2 可能起源于蝙蝠，但它的中间宿主仍在很大程度上未知。在这项研究中，我们组装了从 3 只患病马来亚穿山甲中鉴定出的冠状病毒的完整基因组。分子和系统发育分析表明，这种穿山甲冠状病毒（pangolin-CoV-2020）在遗传上与 SARS-CoV-2 以及一组蝙蝠冠状病毒有关，但不支持 SARS-CoV-2 直接从 pangolin-CoV-2020 中出现。我们的研究表明，穿山甲是β冠状病毒的天然宿主。对穿山甲冠状病毒的大规模监测可以提高我们对穿山甲冠状病毒谱的理解。除了保护野生动物外，减少人类与野生动物的接触对于降低冠状病毒从野生动物溢出到人类的风险也很重要。
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