新型冠状病毒与炎症。
The Novel Coronavirus and Inflammation.
机构信息
Department of Chemical Pathology, National Health Laboratory Services and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Department of Immunology, National Health Laboratory Services and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
出版信息
Adv Exp Med Biol. 2021;1321:127-138. doi: 10.1007/978-3-030-59261-5_11.
The SARS-CoV-2 virus which causes COVID-19 disease was initially described in the Hubei Province of China and has since spread to more than 200 countries and territories of the world. Severe cases of the disease are characterised by release of high levels of pro-inflammatory cytokines and other inflammatory mediators in a process characterised as a cytokine storm. These inflammatory mediators are associated with pathological leukocyte activation states with tissue damage. Here, we review these effects with a focus on their potential use in diagnosis, patient stratification and prognosis, as well as new drug targets.
导致 COVID-19 疾病的 SARS-CoV-2 病毒最初在中国湖北省被描述，此后已传播到世界 200 多个国家和地区。该疾病的严重病例的特征是在细胞因子风暴过程中释放高水平的促炎细胞因子和其他炎症介质。这些炎症介质与具有组织损伤的病理性白细胞激活状态有关。在这里，我们重点回顾这些影响及其在诊断、患者分层和预后以及新药物靶点方面的潜在用途。
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