Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic
BIOCEV, Vestec, Czech Republic.
In Vivo. 2020 Jun;34(3 Suppl):1589-1592. doi: 10.21873/invivo.11947.
COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy.
COVID-19 是一种病毒性呼吸道感染，在老年人或患有严重合并症的人群中常伴有致命性肺部并发症。肺损伤似乎与细胞因子风暴有关，与白细胞介素 6（IL6）水平升高有关。靶向治疗白细胞介素 6 信号通路可以减轻这种细胞因子风暴，对有发生肺衰竭危险的 COVID-19 患者有益。本文展示了 IL6 在疾病进展中的重要性以及抑制 COVID-19 治疗中 IL6 信号的可能性。
