Department of Women's and Children's Health, University of Padova, Padova, Italy.
Department of Developmental Psychology and Socialization, University of Padova, Padova, Italy.
Immun Inflamm Dis. 2021 Jun;9(2):561-568. doi: 10.1002/iid3.418. Epub 2021 Mar 3.
The lockdown imposed by the COVID-19 pandemic resulted in a completely different style of life with possible effects on the attitude toward their disease in patients with chronic lung disease, such as asthma. The aim of our study was to investigate in asthmatic children the level of asthma control and the maintenance therapy used during the lockdown.
Among asthmatic children attending our clinic, we identified those who had been prescribed the same therapy in March-April 2019 and March-April 2020. The level of asthma control (GINA-score) and the maintenance therapy used during the lockdown (March-April 2020) were compared with those of March-April 2019. We separately analyzed a small group of children with severe asthma treated with Omalizumab during the lockdown.
We enrolled 92 asthmatic children (67 males). Compared to 2019, in 2020 a higher proportion of children modified their maintenance therapy (38% vs. 15.2%, p < .001), with a significant increase in both the proportion of children who increased (p = .033) and in that of children who decreased their therapy (p = .026). The level of control resulted as significantly higher in 2020 (March p = .023; April p = .007). Also, the 13 children treated with Omalizumab showed a good level of control in 2020.
In asthmatic children, the COVID-19 pandemic lockdown had a significant impact on their asthma control and on their attitude toward maintenance therapy.
COVID-19 大流行期间实施的封锁导致生活方式发生了巨大变化，这可能会影响慢性肺病（如哮喘）患者对疾病的态度。我们研究的目的是调查哮喘患儿在封锁期间的哮喘控制水平和维持治疗情况。
在我们诊所就诊的哮喘患儿中，我们确定了 2019 年 3 月至 4 月和 2020 年 3 月至 4 月期间接受相同治疗的患儿。比较了哮喘控制水平（GINA 评分）和封锁期间（2020 年 3 月至 4 月）使用的维持治疗，并分别分析了一小部分在封锁期间接受奥马珠单抗治疗的重度哮喘患儿。
我们共纳入 92 名哮喘患儿（67 名男性）。与 2019 年相比，2020 年有更多的患儿调整了维持治疗方案（38%比 15.2%，p<.001），增加治疗方案的患儿比例（p=.033）和减少治疗方案的患儿比例（p=.026）均显著增加。2020 年的控制水平显著提高（3 月 p=.023；4 月 p=.007）。此外，13 名接受奥马珠单抗治疗的患儿在 2020 年也表现出良好的控制水平。
在哮喘患儿中，COVID-19 大流行期间的封锁对其哮喘控制和维持治疗态度产生了重大影响。
