Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Cell Metab. 2021 Mar 2;33(3):463-466. doi: 10.1016/j.cmet.2021.02.008.
Polycystic ovary syndrome (PCOS) is a prevalent reproductive-metabolic disorder with poorly understood etiology. Mimouni et al. (2021) demonstrate global genomic DNA hypomethylation in women with PCOS and their daughters, and in F3 generation PCOS-like mice, together with substantial normalization of PCOS-like mice by methyl donor dietary supplementation.
多囊卵巢综合征（PCOS）是一种常见的生殖代谢疾病，其病因尚不清楚。Mimouni 等人（2021 年）表明，患有 PCOS 的女性及其女儿以及具有 PCOS 样表型的 F3 代小鼠存在全基因组 DNA 低甲基化现象，而通过甲基供体饮食补充可以显著改善 PCOS 样小鼠的表型。
