Division of Allergy, Immunology & Rheumatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Lupus. 2021 May;30(6):946-955. doi: 10.1177/0961203321998749. Epub 2021 Mar 3.
Exercise is considered as an adjuvant therapeutic modality to alleviate symptoms of several rheumatic diseases. However, data regarding the benefits of exercise to patients with systemic lupus erythematosus (SLE) are relatively scant.
This study aimed to assess the effects of regular, moderate-intensity, aerobic exercise combined with resistance training on women with SLE who had no regular exercise. Patients were recruited and allocated into either the exercise or control group by their willingness. Patients in the exercise group (n = 12) underwent 12 weeks of combined exercise (five days per week), whereas those in the control group (n = 11) maintained their usual lifestyle.
At baseline, there were no between-group differences in body composition, disease activity, two-kilometer walking test, and executive function test. After the combined exercise intervention for 12 weeks, significant improvements of both fitness index and reaction time to the stimuli in the go/no-go test were observed in the exercise group, but not in the control group. The disease activities in both study groups did not change significantly at the end of the study period.
Our results suggest that regular moderate-intensity aerobic exercise combined with resistance training improves the physical and executive functions of SLE patients without exacerbating disease activity.
运动被认为是一种辅助治疗方式，可以缓解多种风湿性疾病的症状。然而，关于运动对系统性红斑狼疮（SLE）患者益处的数据相对较少。
本研究旨在评估定期、中等强度、有氧运动结合抗阻训练对无规律运动的 SLE 女性患者的影响。患者根据意愿被招募并分配到运动组或对照组。运动组（n=12）进行 12 周的联合运动（每周 5 天），而对照组（n=11）保持其日常的生活方式。
在基线时，两组在身体成分、疾病活动度、两公里步行测试和执行功能测试方面没有差异。经过 12 周的联合运动干预后，运动组的体能指数和 Go/No-Go 测试中对刺激的反应时间均显著改善，但对照组没有。在研究结束时，两组的疾病活动度均无明显变化。
我们的结果表明，定期的中等强度有氧运动结合抗阻训练可改善 SLE 患者的身体和执行功能，而不会加重疾病活动度。
