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胫腓远侧关节腱鞘巨细胞瘤

Tenosynovial giant cell tumor of the distal tibiofibular joint.

作者信息

Zarate Stephanie D, Joyce David M, Belzarena Ana C

机构信息

Orthopaedic Oncology Department, Miami Cancer Institute, 8900 N Kendall Dr., Miami, FL 33176, USA.

Sarcoma Department, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612, USA.

出版信息

Radiol Case Rep. 2021 Feb 13;16(4):950-955. doi: 10.1016/j.radcr.2021.01.064. eCollection 2021 Apr.

DOI:10.1016/j.radcr.2021.01.064
PMID:33659035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7896125/
Abstract

Tenosynovial giant cell tumors are extremely rare tumors with highly nonspecific symptoms. This benign but aggressive disease has a slow course of progression; however, it can ultimately lead to irreversible damage to a joint. Here we describe a case of a 45-year-old female with a diagnosis of tenosynovial giant cell tumors of the distal tibiofibular joint, the second case described in the literature for such location. Appropriate imaging studies and ultimately histologic studies are necessary for the correct diagnosis. Some locations are particularly unusual for these tumors making a high level of suspicion as well as treatment by an oncology orthopedic surgery specialist at a high-volume center paramount.

摘要

腱鞘巨细胞瘤是极其罕见的肿瘤,症状高度非特异性。这种良性但具有侵袭性的疾病进展缓慢;然而,它最终可能导致关节不可逆转的损伤。在此,我们描述一例45岁女性,诊断为胫腓远端关节腱鞘巨细胞瘤,这是文献中报道的该部位第二例病例。正确诊断需要进行适当的影像学检查以及最终的组织学检查。这些肿瘤在某些部位特别罕见,因此高度怀疑以及由大容量中心的肿瘤整形外科专家进行治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/74142dfa2657/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/bf7d550919df/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/54d1b07ba15a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/6bf50e218e0e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/72a670cdb514/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/74142dfa2657/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/bf7d550919df/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/54d1b07ba15a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/6bf50e218e0e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/72a670cdb514/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e76b/7896125/74142dfa2657/gr5.jpg

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本文引用的文献

1
Tenosynovial giant cell tumor: case report of a patient effectively treated with pexidartinib (PLX3397) and review of the literature.腱鞘巨细胞瘤:一例使用培西达替尼(PLX3397)有效治疗的患者病例报告及文献综述
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Burden of Illness Associated with Tenosynovial Giant Cell Tumors.与腱鞘炎巨细胞瘤相关的疾病负担。
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儿童腱鞘巨细胞瘤:与成人相似的实体。
Clin Orthop Relat Res. 2018 Sep;476(9):1803-1812. doi: 10.1007/s11999.0000000000000102.
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Acta Orthop. 2017 Dec;88(6):688-694. doi: 10.1080/17453674.2017.1361126. Epub 2017 Aug 8.
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Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis).腱鞘巨细胞瘤的局限性和弥漫性形式(以前称为腱鞘巨细胞瘤和色素沉着绒毛结节性滑膜炎)。
Orthop Traumatol Surg Res. 2017 Feb;103(1S):S91-S97. doi: 10.1016/j.otsr.2016.11.002. Epub 2017 Jan 2.
6
Diffuse-type tenosynovial giant cell tumour: Current treatment concepts and future perspectives.弥漫型腱鞘巨细胞瘤:当前的治疗理念和未来展望。
Eur J Cancer. 2016 Aug;63:34-40. doi: 10.1016/j.ejca.2016.04.022. Epub 2016 Jun 5.
7
Tenosynovial giant cell tumors in unusual locations detected by positron emission tomography imaging confused with malignant tumors: report of two cases.通过正电子发射断层成像检测到的罕见部位腱鞘巨细胞瘤与恶性肿瘤混淆:两例报告
BMC Musculoskelet Disord. 2016 Apr 26;17:180. doi: 10.1186/s12891-016-1050-7.
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Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis.腱鞘巨细胞瘤/色素沉着绒毛结节性滑膜炎的当前全身治疗选择:靶向集落刺激因子1/集落刺激因子1受体轴
Curr Treat Options Oncol. 2016 Feb;17(2):10. doi: 10.1007/s11864-015-0385-x.
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Pigmented Villonodular Synovitis: Potential Pitfall on Oncologic 18F-FDG PET/CT.色素沉着绒毛结节性滑膜炎:肿瘤 18F-FDG PET/CT 检查的潜在陷阱。
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Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis.集落刺激因子1的表达与色素沉着绒毛结节性滑膜炎中骨软骨改变的发生相关。
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