激光诱导的角膜损伤：预测阈值的计算机模型的验证
Laser-induced corneal injury: validation of a computer model to predict thresholds.
作者信息
Jean Mathieu, Schulmeister Karl, Lund David J, Stuck Bruce E
机构信息
Seibersdorf Laboratories, Seibersdorf 2444, Austria.
Biophysicist, San Antonio, Texas 78248, USA.
出版信息
Biomed Opt Express. 2020 Dec 15;12(1):336-353. doi: 10.1364/BOE.412102. eCollection 2021 Jan 1.
The exposure and emission limits of ICNIRP, IEC 60825-1 and ANSI Z136.1 to protect the cornea are based on a limited number of studies. To broaden the database, a computer model was developed to predict injury thresholds in the wavelength range from 1050 nm to 10.6 µm and was validated by comparison with all applicable experimental threshold data (ED) with exposure duration between 1.7 ns and 100 s. The model predictions compare favorably with the data with an average ratio of computer prediction to ED of 0.94 (standard deviation ± 30%) and a maximum deviation of less than 2. This computer model can be used to improve exposure limits or for a quantitative risk analysis of a given exposure of the cornea.
国际非电离辐射防护委员会（ICNIRP）、国际电工委员会（IEC）60825-1标准以及美国国家标准学会（ANSI）Z136.1标准中关于保护角膜的暴露和发射限值是基于有限数量的研究制定的。为了拓宽数据库，开发了一种计算机模型，用于预测波长范围在1050纳米至10.6微米之间的损伤阈值，并通过与所有适用的实验阈值数据（ED）进行比较进行了验证，这些实验阈值数据的暴露持续时间在1.7纳秒至100秒之间。该模型预测结果与数据相比表现良好，计算机预测值与ED的平均比值为0.94（标准差±30%），最大偏差小于2。这种计算机模型可用于改进暴露限值或对角膜的特定暴露进行定量风险分析。
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