Xu Chao, Rassel Shazzad, Zhang Steven, Aloraynan Abdulrahman, Ban Dayan
Department of Electrical and Computer Engineering, University of Waterloo, 200 University Ave W, Waterloo, Ontario N2L 3G1, Canada.
Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Ave W, Waterloo, Ontario N2L 3G1, Canada.
Biomed Opt Express. 2020 Dec 24;12(1):666-675. doi: 10.1364/BOE.413086. eCollection 2021 Jan 1.
Based on the breakthrough technology of water muting on photoacoustic spectroscopy, a single wavelength photoacoustic system in the short-wavelength-infrared (SWIR) region was developed to sense the endogenous molecules (e.g. glucose, lactate, triglyceride, and serum albumin found in blood and interstitial fluid) in aqueous media. The system implemented a robust photoacoustic resonant cell that can significantly enhance the signal-to-noise ratio of the acoustic waves. The sensitivity of the system was explored, and the experimental results exhibit a precision detection of physiological concentrations of biomolecules by combining the techniques of water muting and photoacoustic resonant amplification in a portable and low-cost single wavelength laser system.
基于光声光谱中的水静音突破性技术，开发了一种短波长红外（SWIR）区域的单波长光声系统，用于检测水介质中的内源性分子（例如血液和组织液中的葡萄糖、乳酸、甘油三酯和血清白蛋白）。该系统采用了一种强大的光声共振池，可显著提高声波的信噪比。对该系统的灵敏度进行了探索，实验结果表明，通过在便携式低成本单波长激光系统中结合水静音和光声共振放大技术，能够精确检测生物分子的生理浓度。
