Rodgers A, Bateman D N, Woodhouse K W
Department of Clinical Pharmacology, University of Newcastle upon Tyne, UK.
Eur J Clin Pharmacol. 1988;33(6):593-7. doi: 10.1007/BF00542493.
To specifically assess the possible influence of ageing on the changes in theophylline absorption, the plasma concentration-time profiles of sustained-release aminophylline were studied in 8 young and 8 elderly subjects after 9 a.m. and 9 p.m. administration. After 9 p.m. administration, in elderly subjects, maximum plasma theophylline concentrations (Cmax) were decreased, time to maximum concentration (tmax) was increased, and area under plasma concentration-time curve (AUC) was decreased compared to 9 a.m. dosing. This was true for single dose and at steady-state and suggests delayed and diminished absorption at night. No statistically significant changes were seen in the young subjects. This study therefore suggests that time related changes in absorption may be more significant in elderly subjects, possibly due to postural differences after 9 p.m. dosing, and this should be borne in mind when prescribing.
为了具体评估衰老对茶碱吸收变化的可能影响，在上午9点和晚上9点给药后，对8名年轻受试者和8名老年受试者的缓释氨茶碱血浆浓度-时间曲线进行了研究。晚上9点给药后，与上午9点给药相比，老年受试者的血浆茶碱最大浓度（Cmax）降低，达峰时间（tmax）延长，血浆浓度-时间曲线下面积（AUC）减小。单剂量给药和稳态时均是如此，这表明夜间吸收延迟且吸收减少。年轻受试者未观察到统计学上的显著变化。因此，本研究表明，吸收的时间相关变化在老年受试者中可能更显著，这可能是由于晚上9点给药后姿势差异所致，在开处方时应牢记这一点。
