给药时间和年龄对静脉注射氨茶碱药代动力学的影响。
Effects of time of dosing and age on intravenous aminophylline pharmacokinetics.
作者信息
Rodgers A, Woodhouse K W, Bateman D N
出版信息
Br J Clin Pharmacol. 1987 Mar;23(3):344-7. doi: 10.1111/j.1365-2125.1987.tb03055.x.
The elimination kinetics of theophylline were investigated following intravenous administration of aminophylline in 12 subjects (six fit young, and six healthy hospitalised elderly volunteers) at 09.00 h and 21.00 h on separate occasions at least 5 days apart to determine whether time of administration had significant effects on clearance in young and elderly subjects. We were unable to demonstrate a significant change in kinetic parameters between morning and evening administration in either young or elderly subjects. Our results also demonstrated no difference in kinetics between young and elderly subjects. We conclude that neither time of dosing nor age are important determinants of theophylline elimination kinetics in healthy subjects.
在12名受试者（6名健康年轻者和6名住院健康老年人志愿者）中，于不同时间（至少间隔5天）分别在09:00和21:00静脉注射氨茶碱后，研究了茶碱的消除动力学，以确定给药时间对年轻和老年受试者清除率是否有显著影响。我们未能证明年轻或老年受试者在早晨和晚上给药之间动力学参数有显著变化。我们的结果还表明，年轻和老年受试者之间的动力学没有差异。我们得出结论，在健康受试者中，给药时间和年龄都不是茶碱消除动力学的重要决定因素。
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