Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.
Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Immunol Lett. 2021 May;233:87-91. doi: 10.1016/j.imlet.2021.02.006. Epub 2021 Mar 1.
Signal transducers and activators of transcription (STATs) family of proteins are the key signal molecules in the JAK-STAT classical activation pathway of cell biology. STAT6, as a member of the STATs family, is principally activated by IL-4 and IL-13. In addition to Th2 cell differentiation, it plays a crucial role in promoting the development, differentiation, and class switching of B cells. STAT6 deficiency leads to impaired immune function, decreased glycolysis, and morphological changes in B cells, which will help develop various diseases. In this review, we will systematically summarize the major findings of how STAT6 regulates B cells to reveal the potential of STAT6 in treating human diseases.
信号转导子和转录激活子（STATs）家族蛋白是细胞生物学 JAK-STAT 经典激活途径中的关键信号分子。STAT6 作为 STATs 家族的一员，主要被 IL-4 和 IL-13 激活。除了 Th2 细胞分化外，它在促进 B 细胞的发育、分化和类别转换中起着至关重要的作用。STAT6 缺陷导致免疫功能受损、糖酵解减少和 B 细胞形态改变，这将有助于开发各种疾病。在这篇综述中，我们将系统地总结 STAT6 调节 B 细胞的主要发现，以揭示 STAT6 在治疗人类疾病方面的潜力。
