STAT6 在调节 B 细胞命运、激活和功能中的作用。
The roles of STAT6 in regulating B cell fate, activation, and function.
机构信息
Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.
Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China; Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
出版信息
Immunol Lett. 2021 May;233:87-91. doi: 10.1016/j.imlet.2021.02.006. Epub 2021 Mar 1.
Signal transducers and activators of transcription (STATs) family of proteins are the key signal molecules in the JAK-STAT classical activation pathway of cell biology. STAT6, as a member of the STATs family, is principally activated by IL-4 and IL-13. In addition to Th2 cell differentiation, it plays a crucial role in promoting the development, differentiation, and class switching of B cells. STAT6 deficiency leads to impaired immune function, decreased glycolysis, and morphological changes in B cells, which will help develop various diseases. In this review, we will systematically summarize the major findings of how STAT6 regulates B cells to reveal the potential of STAT6 in treating human diseases.
信号转导子和转录激活子（STATs）家族蛋白是细胞生物学 JAK-STAT 经典激活途径中的关键信号分子。STAT6 作为 STATs 家族的一员，主要被 IL-4 和 IL-13 激活。除了 Th2 细胞分化外，它在促进 B 细胞的发育、分化和类别转换中起着至关重要的作用。STAT6 缺陷导致免疫功能受损、糖酵解减少和 B 细胞形态改变，这将有助于开发各种疾病。在这篇综述中，我们将系统地总结 STAT6 调节 B 细胞的主要发现，以揭示 STAT6 在治疗人类疾病方面的潜力。
Zotero 插件