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Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy.

作者信息

Salvi M, Miller A, Wall J R

机构信息

Thyroid Research Unit, McGill University, Montreal General Hospital Research Institute, Quebec, Canada.

出版信息

FEBS Lett. 1988 May 9;232(1):135-9. doi: 10.1016/0014-5793(88)80402-2.

DOI:10.1016/0014-5793(88)80402-2
PMID:3366241
Abstract

A 64 kDa protein has been identified in the membrane fraction of human eye muscle, orbital connective tissue and thyroid, by testing sera of patients with thyroid-associated ophthalmopathy in SDS-polyacrylamide gel electrophoresis and Western blotting. Antibodies to this membrane antigen seem characteristic of the early stage of ophthalmopathy. In the thyroid this newly recognized protein seems different from previously known membrane antigens. A thyroid antibody reactive with a 64 kDa membrane antigen in eye muscle could explain the very frequent association of ophthalmopathy with autoimmune thyroid disease.

摘要

相似文献

1
Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy.
FEBS Lett. 1988 May 9;232(1):135-9. doi: 10.1016/0014-5793(88)80402-2.
2
Antithyroglobulin monoclonal and autoantibodies cross-react with an orbital connective tissue membrane antigen: a possible mechanism for the association of ophthalmopathy with autoimmune thyroid disorders.抗甲状腺球蛋白单克隆抗体和自身抗体与眼眶结缔组织膜抗原发生交叉反应：这可能是眼病与自身免疫性甲状腺疾病相关联的一种机制。
Clin Exp Immunol. 1985 Nov;62(2):361-70.
3
Restricted tissue reactivity of autoantibodies to a 64-kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy.甲状腺相关性眼病中自身抗体对64 kDa眼肌膜抗原的组织反应性受限。
Clin Immunol Immunopathol. 1992 Feb;62(2):183-9. doi: 10.1016/0090-1229(92)90071-u.
4
Prevalence of antibodies reactive with a 64 kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy.甲状腺相关性眼病中与64 kDa眼肌膜抗原反应的抗体的患病率。
Thyroid. 1991 Summer;1(3):207-13. doi: 10.1089/thy.1991.1.207.
5
Native gel electrophoresis and isoelectric focusing of a 64-kilodalton eye muscle protein shows that it is an important target for serum autoantibodies in patients with thyroid-associated ophthalmopathy and not expressed in other skeletal muscle.对一种64千道尔顿的眼肌蛋白进行非变性凝胶电泳和等电聚焦分析表明，它是甲状腺相关眼病患者血清自身抗体的重要靶标，且在其他骨骼肌中不表达。
J Clin Endocrinol Metab. 1995 Apr;80(4):1226-32. doi: 10.1210/jcem.80.4.7714092.
6
Nature of 64 kDa eye muscle and thyroid membrane proteins and their significance in thyroid-associated ophthalmopathy--an hypothesis.
Autoimmunity. 1993;16(2):79-82. doi: 10.3109/08916939308993314.
7
Failure to demonstrate cell-mediated immunity to orbital tissue antigens and epitopic fragments of a 64 kDa protein in the majority of patients with thyroid-associated ophthalmopathy.在大多数甲状腺相关性眼病患者中，未能证明对眼眶组织抗原和一种64 kDa蛋白质的表位片段存在细胞介导的免疫反应。
J Endocrinol Invest. 1996 May;19(5):284-92. doi: 10.1007/BF03347864.
8
Antibodies in the serum of patients with autoimmune thyroid disorders react with a recombinant 98 amino acid fragment of a full length 64 kDa eye muscle membrane protein which is also expressed in the thyroid.
Autoimmunity. 1992;13(2):151-7. doi: 10.3109/08916939209001916.
9
Significance of anti-eye muscle antibody in patients with thyroid-associated ophthalmopathy by quantitative western blot.
Autoimmunity. 1992;14(1):9-16. doi: 10.3109/08916939309077351.
10
Identification of autoantigen recognized by autoimmune ophthalmopathy sera with immunoblotting correlated with orbital computed tomography.通过免疫印迹法鉴定自身免疫性眼病血清所识别的自身抗原，并与眼眶计算机断层扫描相关联。
Clin Immunol Immunopathol. 1992 Nov;65(2):161-6. doi: 10.1016/0090-1229(92)90219-e.

引用本文的文献

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Thyroid-associated Ophthalmopathy.甲状腺相关性眼病
Turk J Ophthalmol. 2017 Apr;47(2):94-105. doi: 10.4274/tjo.80688. Epub 2017 Apr 1.
2
Pathogenesis of thyroid-associated ophthalmopathy: does autoimmunity against calsequestrin and collagen XIII play a role?甲状腺相关性眼病的发病机制：针对肌浆网钙结合蛋白和ⅩⅢ型胶原蛋白的自身免疫是否起作用？
Clin Ophthalmol. 2010 May 14;4:417-25. doi: 10.2147/opth.s6534.
3
Eye muscle antibodies in Graves' ophthalmopathy: pathogenic or secondary epiphenomenon?格雷夫斯眼病中的眼肌抗体：是致病因素还是继发性附带现象？
J Endocrinol Invest. 2004 Mar;27(3):221-9. doi: 10.1007/BF03345270.
4
Pathogenesis of ophthalmopathy in autoimmune thyroid disease.自身免疫性甲状腺疾病中眼病的发病机制。
Rev Endocr Metab Disord. 2000 Jan;1(1-2):87-95. doi: 10.1023/a:1010020621687.
5
High-dose intravenous corticosteroid therapy for Graves' ophthalmopathy.大剂量静脉注射皮质类固醇疗法治疗格雷夫斯眼病。
J Endocrinol Invest. 2001 Mar;24(3):152-8. doi: 10.1007/BF03343835.
6
Thyroid-associated ophthalmopathy in black South Africans with Graves' disease: relationship to serum antibodies reactive against eye muscle and orbital connective tissue autoantigens.南非黑人Graves病患者的甲状腺相关眼病：与抗眼肌和眼眶结缔组织自身抗原反应的血清抗体的关系。
Endocrine. 2000 Dec;13(3):325-8. doi: 10.1385/endo:13:3:325.
7
Immunodetection of manganese superoxide dismutase in cultured human retroocular fibroblasts using sera directed against the thyrotropin receptor.
J Endocrinol Invest. 1998 Jan;21(1):48-55. doi: 10.1007/BF03347286.
8
Antibodies against striated muscle, connective tissue and nuclear antigens in patients with thyroid-associated ophthalmopathy: should Graves' disease be considered a collagen disorder?甲状腺相关眼病患者中抗横纹肌、结缔组织和核抗原抗体：Graves病应被视为一种胶原病吗？
J Endocrinol Invest. 1997 Nov;20(10):585-91. doi: 10.1007/BF03346914.
9
Antibody-dependent cell-mediated cytotoxicity against orbital target cells in thyroid-associated ophthalmopathy and related disorders; close relationship between serum cytotoxic antibodies and parameters of eye muscle dysfunction.甲状腺相关性眼病及相关疾病中针对眼眶靶细胞的抗体依赖性细胞介导的细胞毒性；血清细胞毒性抗体与眼肌功能障碍参数之间的密切关系。
J Endocrinol Invest. 1996 Jun;19(6):334-41. doi: 10.1007/BF03344966.
10
Failure to demonstrate cell-mediated immunity to orbital tissue antigens and epitopic fragments of a 64 kDa protein in the majority of patients with thyroid-associated ophthalmopathy.在大多数甲状腺相关性眼病患者中，未能证明对眼眶组织抗原和一种64 kDa蛋白质的表位片段存在细胞介导的免疫反应。
J Endocrinol Invest. 1996 May;19(5):284-92. doi: 10.1007/BF03347864.