Kim Hyung Suk, Cho Min Chul
Department of Urology, Dongguk University Ilsan Hospital, Dongguk University School of Medicine, Goyang, Korea.
Department of Urology, Seoul Metropolitan Government-Seoul National University (SMG-SNU) Boramae Medical Center, Seoul, Korea.
World J Mens Health. 2022 Jan;40(1):139-148. doi: 10.5534/wjmh.200176. Epub 2021 Feb 17.
To evaluate the correlation between vitamin D level and erectile dysfunction (ED) in male lower urinary tract symptoms (LUTS) patients.
We analyzed data from 534 male patients who were tested for LUTS from 2014 to 2017. LUTS severity was classified into mild (≤7) or moderate to severe (≥8) based on total IPSS scores. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D [25(OH)D] level of less than 20 ng/mL. The severity of ED was dichotomized into mild (≥17 points) or moderate to severe (≤16 points) depending on total IIEF-5 scores. The association of the serum 25(OH)D level with moderate to severe ED was assessed using logistic regression analysis.
In the entire cohort, moderate to severe ED was significantly associated with age ≥60 years (odds ratio [OR], 1.762; 95% confidence interval [CI], 1.011-3.073) and moderate to severe LUTS (OR, 2.075; 95% CI, 1.134-3.789), but not with serum 25(OH)D level (OR, 1.001; 95% CI, 0.979-1.023). Whereas, in the subgroup consisting of moderate to severe LUTS patients over 60 years (n=223), either low serum 25(OH)D level (OR, 0.944; 95% CI, 0.903-0.986) or vitamin D deficiency (OR, 2.949; 95% CI, 1.118-7.782) was the independent risk factor of moderate to severe ED as a result of each multivariate analysis.
Low vitamin D status closely correlated with moderate to severe ED in elderly men with moderate to severe LUTS.
评估男性下尿路症状（LUTS）患者维生素D水平与勃起功能障碍（ED）之间的相关性。
我们分析了2014年至2017年接受LUTS检测的534例男性患者的数据。根据国际前列腺症状评分（IPSS）总分，将LUTS严重程度分为轻度（≤7分）或中度至重度（≥8分）。维生素D缺乏定义为血清25-羟基维生素D [25(OH)D]水平低于20 ng/mL。根据国际勃起功能指数-5（IIEF-5）总分，将ED严重程度分为轻度（≥17分）或中度至重度（≤16分）。采用逻辑回归分析评估血清25(OH)D水平与中度至重度ED的相关性。
在整个队列中，中度至重度ED与年龄≥60岁（比值比[OR]，1.762；95%置信区间[CI]，1.011 - 3.073）和中度至重度LUTS（OR，2.075；95% CI，1.134 - 3.789）显著相关，但与血清25(OH)D水平无关（OR，1.001；95% CI，0.979 - 1.023）。然而，在60岁以上中度至重度LUTS患者亚组（n = 223）中，多因素分析结果显示，低血清25(OH)D水平（OR，0.944；95% CI，0.903 - 0.986）或维生素D缺乏（OR，2.949；95% CI，1.118 - 7.782）均是中度至重度ED的独立危险因素。
在患有中度至重度LUTS的老年男性中，低维生素D状态与中度至重度ED密切相关。
