50岁以上男性的维生素D缺乏与下尿路症状
Vitamin D deficiency and lower urinary tract symptoms in males above 50 years of age.
作者信息
Elshazly Mohamed Abdemonem, Sultan Mohamed Farag, Aboutaleb Hamdy Abdelmawla, Salem Shady Mohamed, Aziz Mohamed Sayedahmed, Abd Elbaky Tarek Mohamed, Elsherif Eid Abdelrasoul, Gawish Maher Mohamed, Alajrawi Feras Tarek, Elgadi Fahd Abdulla Algady, Thaher Awad Husein, Shebl Mohamed Ahmed, Allam Adel Mohamed, Kehinde Elija
机构信息
Department of Urology, Faculty of Medicine, Menoufia University, Shibin Elkom, Egypt.
Department of Urology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
出版信息
Urol Ann. 2017 Apr-Jun;9(2):170-173. doi: 10.4103/0974-7796.204192.
CONTEXT
Lower urinary tract symptoms (LUTSs) in elderly males are usually related to benign prostatic hyperplasia (BPH) in the majority of cases. It is estimated that BPH affects half of men above the age of 50 years. Recently, a relationship between Vitamin D deficiency and LUTS in elderly males has been reported.
AIMS
The aim of this study was to analyze Vitamin D levels in males aged above 50 years presenting with LUTS.
SETTINGS AND DESIGN
This is a prospective case-control study.
PATIENTS AND METHODS
This was a case-control study in which males above 50 years of age who presented with LUTS (Group A) were compared with a control group (Group B) without LUTS. Both groups were investigated regarding Vitamin D level, prostate-specific antigen (PSA), International Prostatic Symptoms Score (IPSS), prostate size, flow rate, serum calcium levels, and abdominal ultrasonography.
STATISTICAL ANALYSIS USED
Statistical software package (SPSS Inc., Chicago, IL, USA) was used for the statistical analyses, performing -test for quantitative data to compare between the two groups. Pearson's correlation coefficient "" test was calculated between two quantitative, continuous variables in Group A. <0.05 was considered statistically significant.
RESULTS
A total of 150 patients were studied. There were 70 and 80 patients in Groups A and B, respectively. The mean age of Group A patients was 60.32 ± 11.93 years versus 58.12 ± 10.55 years for Group B patients ( > 0.05). The mean value of Vitamin D level was 40.82 ± 29.46 nmol/L in Group A and 70.25 ± 22.42 nmol/L in Group B ( < 0.001). The mean value of prostate size was 50.12 ± 23.24 g in Group A and 30.68 ± 4.90 g in Group B ( < 0.001). The mean serum calcium level was 2.4 ± 0.14 mmol/L and 2.50 ± 0.15 mmol/L in Groups A and B, respectively ( < 0.001). The mean value of PSA in Group A was 2.24 ± 1.95 ng/ml versus 2.11 ± 0.45 ng/ml in Group B ( < 0.001). The mean value of IPSS in Group A was 13.38 ± 5.32 ml/s versus 3.41 ± 2.42 ml/s in Group B. The mean value of Q max in uroflowmetry in Group A was 11.5 ± 2 ml/s versus 15.4 ± 1 ml/s in Group B.
CONCLUSIONS
Men older than 50 years of age with LUTS have lower levels of Vitamin D compared to men without LUTS.
背景
在大多数情况下，老年男性的下尿路症状（LUTSs）通常与良性前列腺增生（BPH）有关。据估计，BPH影响半数50岁以上的男性。最近，有报道称老年男性维生素D缺乏与LUTs之间存在关联。
目的
本研究的目的是分析50岁以上出现LUTs的男性的维生素D水平。
设置与设计
这是一项前瞻性病例对照研究。
患者与方法
这是一项病例对照研究，将出现LUTs的50岁以上男性（A组）与无LUTs的对照组（B组）进行比较。对两组进行了维生素D水平、前列腺特异性抗原（PSA）、国际前列腺症状评分（IPSS）、前列腺大小、流速、血清钙水平和腹部超声检查。
所用统计分析方法
使用统计软件包（美国伊利诺伊州芝加哥市SPSS公司）进行统计分析，对定量数据进行t检验以比较两组。计算A组两个定量连续变量之间的Pearson相关系数“r”检验。P<0.05被认为具有统计学意义。
结果
共研究了150例患者。A组和B组分别有70例和80例患者。A组患者的平均年龄为60.32±11.93岁，B组患者为58.12±10.55岁（P>0.05）。A组维生素D水平的平均值为40.82±29.46 nmol/L，B组为70.25±22.42 nmol/L（P<0.001）。A组前列腺大小的平均值为50.12±23.24 g，B组为30.68±4.90 g（P<0.001）。A组和B组的平均血清钙水平分别为2.4±0.14 mmol/L和2.50±0.15 mmol/L（P<0.001）。A组PSA的平均值为2.24±1.95 ng/ml，B组为2.11±0.45 ng/ml（P<0.001）。A组IPSS的平均值为13.38±5.32 ml/s，B组为3.41±2.42 ml/s。A组尿流率中Q max的平均值为11.5±2 ml/s，B组为15.4±1 ml/s。
结论
与无LUTs的男性相比，50岁以上有LUTs的男性维生素D水平较低。
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