Orthopaedic Center of Deyang City, Department of Orthopedics, People's Hospital of Deyang City, Deyang City, 618000, Sichuan, China.
BMC Geriatr. 2021 Mar 4;21(1):155. doi: 10.1186/s12877-021-02102-3.
The systemic immune-inflammation index (SII), based on peripheral platelet, neutrophil and lymphocyte counts, has been proven to be a promising prognostic indicator in various diseases. Hip fracture is a common injury among the older adults, and has become a global public health problem with high mortality and disability rates. However, the relationship between SII and the prognosis of hip fracture is not yet well-known. The aim of the this study was to explore the predictive value of SII in older adults with hip fracture undergoing surgery.
This was a prospective cohort study performed from January 2014 to December 2018 at a orthopaedic center, China. The SII was calculated as platelet×neutrophil/lymphocyte counts. Univariable and multivariable Cox proportional hazard models were used to assess the association between SII and all-cause mortality.
A total of 290 older adults with hip fracture were included, and the mean (SD) age was 77.6 (8.6) years, and 189 (65.2%) were female. The median (IQR) SII was 759.4 (519.0-1128.7) × 10/L. After a median follow-up time of 33.4 months, 13 (4.5%), 26 (9.0%) and 54 (18.6%) patients died within the 30-day, 1-year and last follow-up, respectively. Multivariable Cox analysis revealed that each increase of 100 units of SII was associated with a 8% increased hazard of death at 1-year follow-up (HR = 1.08, 95% CI: 1.01-1.17, p = 0.033), and 9% increased hazard of death at last follow-up (HR = 1.09, 95% CI: 1.03-1.15, p = 0.003).
SII is associated with poor all-cause mortality in older adults with hip fracture undergoing surgery, and deserves further investigation and application in clinical practice.
基于外周血小板、中性粒细胞和淋巴细胞计数的全身免疫炎症指数（SII）已被证明是各种疾病中有前途的预后指标。髋部骨折是老年人常见的损伤，已成为具有高死亡率和残疾率的全球公共卫生问题。然而，SII 与髋部骨折预后之间的关系尚不清楚。本研究旨在探讨 SII 对接受手术治疗的老年髋部骨折患者的预测价值。
这是一项前瞻性队列研究，于 2014 年 1 月至 2018 年 12 月在中国的一家骨科中心进行。SII 计算为血小板×中性粒细胞/淋巴细胞计数。单变量和多变量 Cox 比例风险模型用于评估 SII 与全因死亡率之间的关系。
共纳入 290 例髋部骨折老年患者，平均（SD）年龄为 77.6（8.6）岁，189 例（65.2%）为女性。SII 的中位数（IQR）为 759.4（519.0-1128.7）×10/L。中位随访 33.4 个月后，分别有 13 例（4.5%）、26 例（9.0%）和 54 例（18.6%）患者在 30 天、1 年和最后一次随访时死亡。多变量 Cox 分析显示，SII 每增加 100 个单位，1 年随访时死亡的风险增加 8%（HR=1.08，95%CI：1.01-1.17，p=0.033），最后一次随访时死亡的风险增加 9%（HR=1.09，95%CI：1.03-1.15，p=0.003）。
SII 与接受手术治疗的老年髋部骨折患者的全因死亡率相关，值得进一步研究和临床应用。
