Yilmaz Bilge Kagan, Altin Recep, Sari Alper
Department of Orthopaedic and Traumatology, Afyonkarahisar Health Science University, 03030 Afyonkarahisar, Turkey.
Department of Internal Medicine, Afyonkarahisar Health Science University, 03030 Afyonkarahisar, Turkey.
Diagnostics (Basel). 2025 Jun 18;15(12):1556. doi: 10.3390/diagnostics15121556.
Osteoarthritis (OA) is one of the common joint diseases. Hematologic markers have been investigated to determine its severity and predict the prognosis of joint diseases. In this study, we investigated whether the systemic immune-inflammatory index (SII) is a marker for assessing the severity of OA. : The records of patients diagnosed with OA at various stages between 1 January 2020 and 1 January 2022 were retrospectively analyzed. Patients aged 18-75 years with complete blood count within the last 15 days and not taking anti-inflammatory drugs were included in the study. Patients were classified according to the Kellgren-Lawrance classification as stage 1-2-3 mild to moderate OA (Group I) and stage 4 severe OA (Group II). A total of 1580 patients were diagnosed with knee OA and 946 were included in the study. Of the patients, 246 (26%) were male and 700 (74%) were female. The mean age of the patients was 61.00 (53.00-68.00) years. : There were 449 (47.5%) patients in Group I and 497 (52.5%) patients in Group II. Statistically significant differences were found between the groups in age, gender, hemoglobin, lymphocytes, and SII ( < 0.05). An SII value of 627.9 was found to distinguish severe OA from mild-moderate OA with 42.5% sensitivity and 70.6% specificity. : Although this study is the first in the literature, it shows that SII has limited predictive value in assessing the severity of knee OA. Future research should focus on longitudinal studies to establish causality and explore therapeutic implications.
骨关节炎（OA）是常见的关节疾病之一。人们已经对血液学标志物进行了研究，以确定其严重程度并预测关节疾病的预后。在本研究中，我们调查了全身免疫炎症指数（SII）是否为评估OA严重程度的标志物。：回顾性分析了2020年1月1日至2022年1月1日期间不同阶段诊断为OA的患者记录。纳入研究的患者年龄在18 - 75岁之间，在过去15天内进行过全血细胞计数且未服用抗炎药物。根据凯尔格伦 - 劳伦斯分类法，患者被分为1 - 2 - 3期轻度至中度OA（第一组）和4期重度OA（第二组）。共有1580例患者被诊断为膝骨关节炎，946例纳入研究。其中，男性246例（26%），女性700例（74%）。患者的平均年龄为61.00（53.00 - 68.00）岁。：第一组有449例（47.5%）患者，第二组有497例（52.5%）患者。两组在年龄、性别、血红蛋白、淋巴细胞和SII方面存在统计学显著差异（<0.05）。发现SII值为627.9时，区分重度OA与轻度至中度OA的敏感性为42.5%，特异性为70.6%。：尽管本研究在文献中尚属首次，但表明SII在评估膝骨关节炎严重程度方面的预测价值有限。未来的研究应侧重于纵向研究以确定因果关系并探索治疗意义。
