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氯硝西泮诱导的苔藓样药物疹:一例报告。

Clonazepam-induced lichenoid drug eruption: a case report.

机构信息

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.

Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.

出版信息

BMC Psychiatry. 2021 Mar 4;21(1):125. doi: 10.1186/s12888-021-03132-2.

Abstract

BACKGROUND

Lichenoid drug eruption is rare and can mimic idiopathic lichen planus and other dermatoses. Clonazepam, a commonly used drug for the treatment of anxiety-related disorders and seizures, is known to be an unlikely cause of cutaneous adverse effects. Only one case report of LDE due to clonazepam has been reported.

CASE PRESENTATION

A 81-year-old male patient with Alzheimer's disease developed a lichenoid eruption after taking clonazepam. He developed a violaceous scaly patch on his lower extremities, from both buttocks to the feet. The cutaneous eruption resolved 2 months after cessation of clonazepam and with initiation of corticosteroid therapy.

CONCLUSION

A skin eruption that develops after clonazepam administration can be a lichenoid drug eruption, which is less likely to resolve spontaneously and requires discontinuation of clonazepam administration.

摘要

背景

苔藓样药疹罕见,可模仿特发性扁平苔藓和其他皮肤病。氯硝西泮是一种常用于治疗焦虑相关障碍和癫痫的药物,其导致皮肤不良反应的可能性不大。仅有一例因氯硝西泮引起的 LDE 的病例报告。

病例介绍

一名 81 岁男性阿尔茨海默病患者在服用氯硝西泮后出现苔藓样疹。他的下肢从臀部到脚部出现紫红色鳞屑性斑块。在停用氯硝西泮并开始皮质类固醇治疗 2 个月后,皮肤疹消退。

结论

在氯硝西泮给药后出现的皮疹可能是苔藓样药疹,其不太可能自发消退,需要停止氯硝西泮给药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15e2/7934486/f315678c1332/12888_2021_3132_Fig1_HTML.jpg

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