Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
BMC Psychiatry. 2021 Mar 4;21(1):125. doi: 10.1186/s12888-021-03132-2.
Lichenoid drug eruption is rare and can mimic idiopathic lichen planus and other dermatoses. Clonazepam, a commonly used drug for the treatment of anxiety-related disorders and seizures, is known to be an unlikely cause of cutaneous adverse effects. Only one case report of LDE due to clonazepam has been reported.
A 81-year-old male patient with Alzheimer's disease developed a lichenoid eruption after taking clonazepam. He developed a violaceous scaly patch on his lower extremities, from both buttocks to the feet. The cutaneous eruption resolved 2 months after cessation of clonazepam and with initiation of corticosteroid therapy.
A skin eruption that develops after clonazepam administration can be a lichenoid drug eruption, which is less likely to resolve spontaneously and requires discontinuation of clonazepam administration.
苔藓样药疹罕见，可模仿特发性扁平苔藓和其他皮肤病。氯硝西泮是一种常用于治疗焦虑相关障碍和癫痫的药物，其导致皮肤不良反应的可能性不大。仅有一例因氯硝西泮引起的 LDE 的病例报告。
一名 81 岁男性阿尔茨海默病患者在服用氯硝西泮后出现苔藓样疹。他的下肢从臀部到脚部出现紫红色鳞屑性斑块。在停用氯硝西泮并开始皮质类固醇治疗 2 个月后，皮肤疹消退。
在氯硝西泮给药后出现的皮疹可能是苔藓样药疹，其不太可能自发消退，需要停止氯硝西泮给药。
