Shim J H, Kim T Y, Kim H O, Kim C W
Department of Dermatology, Catholic University Medical College, Seoul, Korea.
Dermatology. 1995;191(2):142-4. doi: 10.1159/000246533.
A 65-year-old male patient who has taken antituberculous drugs including cycloserine for 8 months showed multiple pruritic, violaceous, flat-topped papules and plaques on his back which had developed 5 months into therapy. Histopathologic findings were consistent with lichenoid drug eruption. Patch test with the drugs revealed a strongly positive reaction to cycloserine only. Four months after discontinuation of oral cycloserine, pruritus resolved and the lesions subsided without any new lesions. Cycloserine is one of the antituberculous drugs. Skin manifestations resulting from its administration are reported to be rare, but to our knowledge, this is the first case report of lichenoid drug eruption from its use.
一名65岁男性患者服用包括环丝氨酸在内的抗结核药物8个月，在治疗5个月时背部出现多发瘙痒性、紫罗兰色、平顶丘疹和斑块。组织病理学检查结果符合苔藓样药疹。对这些药物进行斑贴试验，结果仅显示对环丝氨酸有强阳性反应。停用口服环丝氨酸4个月后，瘙痒消退，皮损消退且无新皮损出现。环丝氨酸是抗结核药物之一。据报道，其用药引起的皮肤表现罕见，但据我们所知，这是首例因使用环丝氨酸导致苔藓样药疹的病例报告。
