Forouzan Parnia, Riahi Ryan R, Cohen Philip R
Dermatology, University of Texas Medical School, Houston, USA.
Dermatology, DermSurgery Associates, Sugar Land, USA.
Cureus. 2020 Mar 1;12(3):e7155. doi: 10.7759/cureus.7155.
Statin medications [3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors] are generally used to treat hypercholesterolemia. Lichenoid drug eruptions are a potential cutaneous side effect of medications including antibiotics, antimalarials, and statins. This drug eruption can mimic features of idiopathic lichen planus in clinical presentation and pathology. We describe the case of a 73-year-old man who developed a lichenoid drug eruption secondary to atorvastatin. His clinical features, in addition to histological findings, helped to establish the diagnosis. The cutaneous eruption resolved one month after the cessation of atorvastatin and with corticosteroid therapy. Statins have been associated with adverse events including bullous dermatosis, eosinophilic fasciitis, lichenoid drug eruption, and phototoxicity. Lichenoid drug eruption associated with statin therapy requires discontinuation of the statin medication; an alternative class of medication for the treatment of hypercholesterolemia is usually necessary.
他汀类药物[3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂]通常用于治疗高胆固醇血症。苔藓样药疹是包括抗生素、抗疟药和他汀类药物在内的药物潜在的皮肤副作用。这种药疹在临床表现和病理上可模仿特发性扁平苔藓的特征。我们描述了一名73岁男性患者，他因阿托伐他汀继发苔藓样药疹。他的临床特征以及组织学检查结果有助于确诊。停用阿托伐他汀并给予皮质类固醇治疗后，皮肤疹在1个月后消退。他汀类药物已与包括大疱性皮肤病、嗜酸性筋膜炎、苔藓样药疹和光毒性在内的不良事件相关。与他汀类药物治疗相关的苔藓样药疹需要停用他汀类药物；通常需要换用另一类药物来治疗高胆固醇血症。
