Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Department of Clinical Medicine, Peking Union Medical College, No. 5 Dongdan Three Street, Beijing, China.
Syst Rev. 2021 Mar 4;10(1):66. doi: 10.1186/s13643-021-01607-7.
Stroke is the second leading cause of death worldwide, and 53.4% of stroke survivors suffer from post-stroke cognitive impairment. Post-stroke cognitive impairment can increase hospitalization rate and cost of care and decrease the quality of life of stroke patients. To date, multiple cognitive rehabilitation interventions have been tested in stroke populations with post-stroke cognitive impairment. However, the most efficacious intervention has not been established. This systematic review aims to compare the efficacy of cognitive rehabilitation interventions for patients with post-stroke cognitive impairment.
We will search MEDLINE, EMBASE, CENTRAL, PsycINFO, CINAHL, PubMed, and clinical trial registries to identify eligible randomized clinical trials with no restrictions in the date of publication and language. Studies conducted with patients aged 18 or over, with the presence of cognitive impairment after being diagnosed with stroke will be included. Studies will be restricted to randomized controlled trials comparing a cognitive rehabilitation intervention with another intervention. The primary outcome is any clinical changes in the general or specific cognitive domain (e.g., executive function, attention, memory, or perception). The secondary outcomes that will be collected include adverse effects (e.g., stroke, disability, or mortality) and quality of life. Two independent reviewers will assess articles to identify trials eligible for inclusion. Data extraction and risk of bias assessment of the included studies will also be done independently. Any discrepancies will be solved by discussion, or a third reviewer will be consulted if necessary. A meta-analysis will be carried out if appropriate.
This systematic review for patients with post-stroke cognitive impairment will assess the efficacy of cognitive rehabilitation interventions. And our results will help clinical decision-making and support the development of clinical practice guidelines.
Systematic review registration: PROSPERO CRD42020173988.
中风是全球第二大致死原因，53.4%的中风幸存者患有中风后认知障碍。中风后认知障碍会增加住院率和护理成本，降低中风患者的生活质量。迄今为止，已经有多种认知康复干预措施在患有中风后认知障碍的人群中进行了测试。然而，最有效的干预措施尚未确定。本系统评价旨在比较认知康复干预措施对中风后认知障碍患者的疗效。
我们将检索 MEDLINE、EMBASE、CENTRAL、PsycINFO、CINAHL、PubMed 和临床试验注册库，以确定无发表日期和语言限制的合格随机临床试验。研究对象为年龄在 18 岁或以上、被诊断为中风后存在认知障碍的患者。研究将仅限于比较认知康复干预与其他干预的随机对照试验。主要结局是一般或特定认知领域（如执行功能、注意力、记忆或感知）的任何临床变化。将收集的次要结局包括不良反应（如中风、残疾或死亡）和生活质量。两名独立的审查员将评估文章，以确定符合纳入标准的试验。还将独立进行纳入研究的数据提取和偏倚风险评估。如有分歧，将通过讨论解决，必要时咨询第三位审查员。如果合适，将进行荟萃分析。
本系统评价针对中风后认知障碍患者，将评估认知康复干预措施的疗效。我们的研究结果将有助于临床决策，并支持临床实践指南的制定。
系统评价注册：PROSPERO CRD42020173988。
